Wednesday, August 07, 2013

Why Is the First IVF Cycle the Toughest?

Women are understandably greatly disappointed when their first IVF cycle is unsuccessful. Some of them even abandon the hope of ever having a baby after their first IVF cycle fails. This is truly tragic because the second IVF cycle is often much easier than the first.

Firstly, the patient knows exactly what awaits them and is well aware of the fact that IVF treatment does not involve any surgery or pain. 

Secondly, because the patient now knows the doctor and the nurses more closely, their comfort level is raised.

Finally, what is most important is that patients have more realistic hopes from the second IVF cycle. Usually too many expectations are pinned on the first IVF cycle. Patients believe that because they have put in so much effort, time and money into it, god will surely know that they deserve success. They also overrate the ability of modern IVF technology to achieve success . Because their doctor is very hopeful or because their embryos are of grade A quality, patients feel that there is no way their IVF cycle can fail, since they have done everything perfectly.

Unfortunately, it doesn’t always work that way. Most IVF cycles fail due to factors well beyond the control of the physician or the patient.  Getting pregnant, whether naturally or with the assistance of technology, remains a matter of chance.

Those who have faced IVF failures successfully have increased emotional strength. They are better equipped to deal with the turbulence involved in IVF treatment and therefore are more relaxed, no matter what the outcome is.

Not just for the patient, but the second IVF cycle is much easier for the doctor too.The doctor knows exactly how your body responds, and can tailor your treatment protocol accordingly.

Have you failed an IVF cycle, and are unsure of what to do next ? Please send me your medical details by filling in the form at so that I can guide you better !


  1. Anonymous10:58 PM

    Hello Dr!

    I just had my 1st IVF. Had beta checked today (9 days post embryo transfers) but HCG is only 12. Have been told I am likely miscarrying or ectopic. Have you seen any HCGs this low develop into a viable pregnancy?

    Thank you

  2. Was this a Day 3 or a Day 5
    transfer ?

  3. Anonymous4:10 AM

    Unfortunately day 5 transfers- so I am aware HCG should be higher

  4. I agree such a low HCG is worrisome. Normally, 14 days after ovulation ( 9 DP D5 ET) it should be about 100 mIU/ml


    Repeat the test in 2 days. If this is a healthy pregnancy, it should double

    We look forward to helping you to have a baby !

    Dr Aniruddha Malpani, MD
    Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
    Bombay 400 005. India
    Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

    Helping you to build your family !

    PS Watch our infertility cartoon film at

    Read our book, How to Have a Baby – A Guide for the Infertile Couple,
    Online at !

    Read my blog about improving the doctor-patient
    Relationship at

  5. Anonymous4:58 PM

    Thank you- I am scheduled a test tomorrow. If it doubles is there still a chance for me?

  6. Anonymous9:53 PM

    Hello Dr!

    Its me again! Just to let you know- my repeat beta went from 12 to 57 and is now 225!

    Any thoughts?

  7. This is encouraging news ! Can you send me the levels and the dates on which they were done so I can interpret these intelligently ?


    Repeat the test in 2 days. If this is a healthy pregnancy, it should double

  8. Anonymous2:25 AM

    Thank you for your message. These were all done every 48hrs.

    Dates are: 10/8/13 (9days post day5transfer)= 12
    12/8/13 = 57
    14/8/13 = 225
    Thanks for your input!

  9. Good, this is encouraging

    Once the HCG crosses 1000 mIU/ml, you need to do a vaginal ultrasound scan to confirm all is well



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