Thursday, January 06, 2011

Testing for pregnancy after an embryo transfer in an IVF cycle

While all IVF patients understand with their heads that not every IVF cycle results in success, in their heart of hearts, every patient expects to get pregnant every time they do IVF ! This is why the 2ww after the embryo transfer can be so nerve-wracking ! Am I pregnant or not ? Have the embryos implanted or not ? The suspense during the 2ww can be even worse than the pain of the IVF injections !

Most patients would love to have a test which will allow them to find out if they are pregnant immediately after the embryo transfer ! Have the embryos stuck or not ? Why can’t we do a pregnancy test and find out right now ? Even if I am not pregnant, at least it’s better to know than to be unsure.

To understand why patients ( and their doctors ) still have to suffer through a 2 week wait to find out the outcome of an IVF cycle, let’s look at the biological basis of pregnancy tests and how they work.

A pregnancy test measures the amount of beta hCG ( human chorionic gonadotropin) that is in your body. HCG is a hormone which is produced by the trophectoderm cells of the embryo. It is produced in detectable quantities only after the embryo implants. Since implantation occurs 3 - 8 days after the embryo transfer ( depending upon whether you have had a Day 3 transfer or a blastocyst transfer), this means that the HCG produced by your embryo will be first detectable in your bloodstream only after this time.

As your pregnancy progresses, the amount of hCG in your system will increase. At 10 days past ovulation ( DPO) , for example, the average woman has an hCG measurement of around 25 mIU. This amount doubles to 50 mIU at 12 days past ovulation, and then doubles again to 100 mIU at around two weeks past ovulation. Every woman’s body is different, and there’s a lot of variation in HCG levels from woman to woman !

Home pregnancy tests measure the level of HCG in urine. Different pregnancy tests have different levels of sensitivity which means if you use a home pregnancy test that is sensitive to 100 mIU, it will not tell you that you are pregnant if your level of hCG is only 75 mIU. These tests cannot measure a level lower than 25, so they do not become accurate until a few days after embryo implantation. A negative result before then is meaningless, since there would not be a high enough level of HCG to detect even if you were pregnant. If your test is negative, you should retest after 2 days. This is why taking a pregnancy test too early can lead to inaccurate results. I know it’s hard to wait those extra days and you may want to try much earlier. It’s fine to do this, but please don’t assume that a negative results means that you are not pregnant.
This is also why blood tests for HCG are much better than urine tests. Not only are they more reliable, accurate and sensitive, they also give the doctor a number which he can measure and monitor.

If blood tests are so sensitive, then why not do a blood test for HCG 1 week after the embryo transfer ? Unfortunately, doing a blood test for HCG so soon does not make any sense. This is because there will still be some HCG in your body as a result of the HCG trigger shot ( Choragon or Ovidrel) which the doctor gave you to trigger off ovulation 36 hours prior to egg collection. If you test too early, the test will always be positive, as this HCG will show up in the test and give rise to false hopes ! This is why the doctor needs to repeat the blood test for HCG after 48-72 hours. In a healthy pregnancy, the HCG levels will continue to rise. If they do not do so, this means this is not a viable pregnancy.

Finally, remember that you should do the test even if you bleed. Bleeding can sometimes occur during pregnancy as well – and just because you have had bleeding or spotting does not mean you are not pregnant !


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110 comments:

  1. Anonymous1:25 PM

    Wat abt egg donor cycle ivf.? can they do pregnancy test after 1 week?

    ReplyDelete
  2. A HCG blood test is best done 12 days after a Day 3 transfer. Even though it can give a positive result before this, doing it too early does not help.

    ReplyDelete
  3. Anonymous10:12 PM

    Pls Dr does a -ve result from a home urine test on day 12 after ET mean it's over? I had some brownish spotting today day 12. Had a day 3 transfer of 3 embryos. Thank u.

    ReplyDelete
  4. I am sorry, but a negative urine test is not a good sign and suggests the cycle has failed.

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  5. Anonymous7:14 PM

    Dr..today is 7th day after embryo transfer.my E2 level is 61..madam prescribe me progynova( daily 2).is there any hope? Can i became pregnant?

    ReplyDelete
  6. It's very unusual to test for E2 levels after the transfer !

    We routinely provide luteal phase support with estrogen and progesterone to all our IVF patients.

    Best of luck !

    ReplyDelete
  7. dis is my second ivf cycle with frozen embryos..my bhcg test is negative..but doc asked me to continue meds till upt..but on 10th day i started noticing spotting..today is day 12..why is it so??

    ReplyDelete
  8. How many days back was the ET done ? Was this a Day 3 or Day 5 transfer ?

    If the blood test is negative , there's little point in doing a UPT

    Can you send me more details about your IVF cycles ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  9. Anonymous4:31 PM

    Hi Dr, today is my 10 day of ET. 3 EMBRYO, 3 day embryo transfer. before i had 2 pregnancy with miss abortion. both the time it was chromosome abnormality. so this time we did IMSI. now after 8 day of transfer i feel little cramp in lower abdomen right side. I m still on progestrone suppliment, when can i do home pregnancy test?

    ReplyDelete
  10. How will IMSI prevent a chromosomal abnormality ??

    Do a blood test for HCG to find out if you are pregnant.

    Read more at www.drmalpani.com/hcg.htm

    Dr Aniruddha Malpani, MD
    Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
    Bombay 400 005. India
    Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

    Helping you to build your family !

    My Facebook page is at www.facebook.com/Dr.Malpani

    You can follow me on twitter at https://twitter.com/drmalpani

    Watch our infertility cartoon film at http://www.ivfindia.com

    Read our book, How to Have a Baby - A Guide for the Infertile Couple,
    online at www.DrMalpani.com !

    Read my blog about improving the doctor-patient
    relationship at http://blog.drmalpani.com



    ReplyDelete
    Replies
    1. Anonymous5:15 PM

      I had 3 good eggs transfered 11 days ago, 5 day blastocycts transfer on march 21st... and this morning I took a clear blue easy digital hpt and it says Not Pregnant. Im sooo upset. I would think from everything Ive read that my hcg levels would be detectable by now, no? This will be my 3rd failed cycle if this doesnt work, and im just beside myself. :(

      Delete
  11. Anonymous6:25 PM

    embryo transfered after 3 dys of retreival,today negative urine hpt test today also we have the blood test ,medicines taken suprefact and puregon ,other supplements for progesterone cyclogest and progynova,first 2 blood test showed 190.8 progesterone the third went down to 56 and 17.9 ng/ml ,2 fertilized were transferred .

    ReplyDelete
  12. 8dp3dt fresh three 10 cell grade 1.5 embryos (ICSI & AH)
    Remaining 6 all fertilized & made it to cryopreservation
    10,000U Pregnyl given 1.5days b4 ER (13 days ago)
    HPT + today
    Beta in 3 days
    Pregnant?

    ReplyDelete
  13. Dear doctor,I had my ET On 5th of April-2013,it was in day 3rd after ER on 2nd of april,befor the transfer my doc said I Have high progesteron lable in my blood i.e.1.38,she suggested me to wait untill next cycle as they had 8good quality of embroy,the chief embroylogist asked me to frozen it.but as being dipress i insisted to go for this time only.they transfered 2embroys out of 8,and rest 6they kepted fr frozen,i am taking geston 100mg evryday as in inj.ang fragmin2500IU evryday along with following medicines,tab progynova,duphoston,ecosprin,empholic dha for next 17days,so still even after having high progesteron lable do ihavr chance to get positive result?I get some cramps during the day,and feel heavy in mylower abdomin,can you please help me out,i also had mild PCo due to that i m also taking metformin 500mg three times a day from past 3years.

    ReplyDelete
  14. Dear Vanishka,

    A progesterone level of 1.38 is very low !

    Do you have photos of your embryos ?

    ReplyDelete
  15. Anonymous11:16 AM

    Dear Dr, E2 level of 254 and progesterone level of 16.1, 7 days after embryo transfer (5 day), can it be considered as the enough level to conceive? Please suggest, if u think that my progesterone dose should be increased.
    Thank you!

    ReplyDelete
  16. Anonymous2:13 AM

    respected Dr
    i had my ET on 5th April...transfered 2 embrios on day 5. i am on utrogestane. on my 9dpt i started to spot which become heavy bleeding on the next two days. my dr said continue utrogestane until the test day. im very upset. does bleeding means its over.

    ReplyDelete
  17. Heavy bleeding is usually a bad sign and suggests your Day 5 embryos have not implanted, sorry !

    ReplyDelete
  18. Anonymous12:14 AM

    I am 6dpt (1 frozen blastocyst). When do you think I could expect to see my first positive home pregnancy test?

    ReplyDelete
  19. You can start testing 9 days post transfer, but home pregnancy tests are not always reliable !

    Read more at www.drmalpani.com/hcg.htm

    ReplyDelete
  20. Anonymous10:26 AM

    Hello doctor,
    I had my 3day embryo transfer. 2 embryo both grade A embryo were transferred on 18th April. I was given 2 hcg inj named ovipure hp 2000iu each on 18th and 22nd April after transfer. And was also given ovidrel 500 for ovalution before egg retrival. My 1st beta hcg was on 30th April result 49.8 and 2nd on 3rd may result 51.25. What was the reason my levels dint increased. Could it happen tht both embryo implanted and one dint survived or there was still traces of hcg in my blood on my 1st beta hcg test day. Or some other reason my hcg dint increased.plz reply

    ReplyDelete
  21. The fact that the HCG did not rise means this is not a viable pregnancy, sorry

    This maybe a chemical pregnancy . You can read more about this at www.drmalpani.com/chemicalpregnancy.htm

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  22. Anonymous12:25 PM

    Thanks for ur reply doctor but I m told to do another blood test on 6th April. Can my levels double or increase. Can it happen tht initially hcg levels doesn't rise but later it could rise.

    ReplyDelete
  23. Anonymous6:55 PM

    Hi l am just wondering if 7 days after day 2 embryo transfer is too early to do hpt ,l did one this morning with a very faint positive ?????

    ReplyDelete
  24. Anonymous4:24 PM

    This is my second ivf d first one fail coz of thin endrometrium but for d second one the thickness was 7.5 and 4 embryos were transfer after day 2egg retrival even my hubby saw d egg were so fine am supose to do my prg test en today is my 11 day but i just feel heavy at my bottom but i dont feel any cramp so am worried and am on cylgest and femoston to increase my endo thickness which am takin 4 tablets daily

    ReplyDelete
  25. Anonymous5:59 PM

    Hello Dr,
    Just did my pregnancy test after an ivf transfer which was done on the 27of april, I had no spotting, no bleeding and the test result is still negative. Is it possible to be pregnant and still have a negative result?

    ReplyDelete
  26. It's a bit too early . A faint positive urine pregnancy test could be because of the HCG trigger shot prior to egg collection

    ReplyDelete
  27. While a positive pregnancy test is encouraging, a negative test is not always reliable. However, a negative test 14 days after embryo transfer is usually not good news. However, it's important to do a blood test for HCG to confirm the results

    ReplyDelete
  28. Anonymous10:36 PM

    I am on day 9 of a 5 day egg transfer I done a test and it was negative just wondering if ihave done it to soon or has it failed

    ReplyDelete
  29. Anonymous3:46 PM

    Hello
    I have just had IVF my second treatment with 2 frozen embryos I did a pregnancy test 8 days after I had them transfers I also did a pregnancy test today. Day 12 and both have come up and said pregnant I know I have only got 2 days left for my blood test but is it a good sign the test said 3 min wait but the pregnancy sign came up way before that

    ReplyDelete
  30. Yes, this is a good sign and suggests you are pregnant - congrats !

    ReplyDelete
  31. Anonymous8:20 PM

    Hello Dr. Malpani, My Cryo-ET of 2 Blastocysts done on 09/05/2013. My Dr. prescribed me to take Inj. Corion 2000iu IM on 09/05/2013, 11/05/2013 and 14/05/2013 alongwith Gestum (inj. and capsule alternate day). My beta-HCG level on 18/05/2013 was 140.9 (fasting) and on 20/05/2013 was 189.1 (after lunch). How good is this for pregnancy?

    ReplyDelete
  32. Anonymous12:22 PM

    Hi i m having unocornaute uterus and low amh.I had soft ivf cycle produced,3 eggs from 3 follicles resulted into 3 embroys but had only 1 3day transfer.what are my chances to concieve?Can in next cycle i can have 2 fet?

    ReplyDelete
  33. Anonymous11:29 PM

    hello doctor,i undergo five times ivf treatment but results fail.now Iam 16weeks pregnant and now bleeding is coming sometimes with clotted blood but our doctor says just let that come out,she wont giving any tablets for that.But I consult other doctor for verification,she gives ecospirin-75 for 32weeks and maintane(allylestrenol tablets) for 10days to reduce the bleedin.i have doubt that shall I take those tablets.thank you in advance.

    ReplyDelete
  34. Anonymous12:47 AM

    Hi Dr, I had 2nd cycle of ivf done with 3 A grade n 1AB grade frozen embryos transferred on day 3. Today on 13 day after ET my hcg level is <1.2 . Is there any hope? I have no spotting or bleeding. Only cramps. I have undergone 3 iui n 2 ivf cycles. I'm depressed. Please guide.

    ReplyDelete
  35. Hi!
    I have a negative blood pregnancy test after 15 days of natural cycle ivf . 3 days old 6 cells embryo transfer. I
    Do I have any hope of being pregnant ?

    ReplyDelete
  36. Dear Mariely,

    No, sorry, this means the embryo did not implant :(

    Can you send me more details about your IVF cycle ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  37. Anonymous8:58 AM

    I did by home urine preg test (using a kit which claims to be sensitive to 10 mIU) after6days post 5day embryo transfer . It is negative . Is the test reliable at this stage so does this mean cycle failed?

    ReplyDelete
  38. Please do the HCG blood test as planned. This is much more reliable. Read more at www.drmalpani.com/hcg.htm

    ReplyDelete
  39. Anonymous11:13 PM

    i had 2 embryos transferred on 6/12/13. first test positive hcg 530.2nd test hcg 1200 and 3rd blood test 2400.today 7/1/13.after using the bathroom,saw a little blood clot on the tissue.does it mean that i LOST THE PREGNANCY.

    ReplyDelete
  40. Spotting and bleeding during pregnancy is quite common. This usually comes from the uterus and does not harm the baby, so please
    Do not worry about it ! Just rest and drink lots of fluids and it should stop.


    You need to do a vaginal ultrasound scan to confirm the pregnancy is healthy

    Read more at http://www.drmalpani.com/early_pregnancy_scans_atlas.htm

    Dr Malpani

    ReplyDelete
  41. Marilynn11:59 AM

    Hi Doc,
    I have my embryo transfer on 26th June 2013. I had 9 embryos, 3 fertilized and only 2 transferred on day 2...grade 3 and grade 4. I don't have much symptoms, laps of mild cramps. My blood test will be on 12th July. My 1st time doing ICSI and I'm quite worried if it doesn't work. I'm on utrogeston vaginal. 3 times a day. Will that help me getting pregnant? I've been trying to conceive for the past 8years. Did 2 rounds of IUI in 2009 which failed. The embryo was transfer 3days before my period. And I'm now 4 days late for my period. Does that mean implantation doing well and I will be pregnant? Can I do a home pregnancy test?

    ReplyDelete
  42. Dear Marilynn,

    These seem to be poor quality embryos, which is worrisome.

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  43. Anonymous4:54 PM

    Dr good afternoon, pls I had my 5day ET on the 22nd of june, 3 grade A and 3 grade B . six embryos in all. my pregnancy test is scheduled in the clinic on the 5th of july. but I did a home pregnancy test this monrn 3rd of july which said positive. I did yesterday and the day before, and they were all positive. does it mean am pregnant? pls reply me am so anxious!!!

    ReplyDelete
  44. ifeoma5:01 PM

    hello, Dr malpani I had my ET on the 22/6/13. I had 6 embryos transferred. 3 grade A and 3 grade B. my blood pregnancy test is scheduled on the 5/7/13. but I did a home pregnancy test this morning, 3/7/13 and it was positive. I did yesterday and a day before it was all positive. does it mean am pregnant or is it the follicle stimulating homrmones I took prior to egg collection. pls reply.

    ReplyDelete
  45. Marilynn5:37 PM

    Hi doc,
    My icsi was in Singapore and the embryologist told me that grading is 1-5 and 4 is consider very good as the best is 5.
    Probably it's different.

    ReplyDelete
  46. A positive home pregnancy test is usually a good sign and means you are pregnant.

    Is the test band becoming darker with each day ?

    Why would any clinic transfer 6 blastocysts ? That's very worrisome because of the risk of multiple pregnancies.

    ReplyDelete
  47. Dear Marilynn,

    I most clinics, Grade 1 is the best !

    That's the advantage of having photos - these are objective and much more reliable !

    How many cells did your embryos
    have ?

    Of 9 eggs, why did only 3 fertilise ?

    Fertilisation rates are usually much better

    ReplyDelete
  48. Marilynn6:16 PM

    Hi doc,
    In Singapore you are only allowed max 2eggs to be transferred. I have checked your embryo page. It's exactly like my embryo pic 2days 4cells. I do have my embryo pictures given to me.
    Over here they don't give us the reports and if egg quality is bad no transfer will be done as our govt co fund half of the cost.

    ReplyDelete
  49. In most clinics, the transfer is done on Day 3 or Day 5

    Best of luck !

    Dr Malpani

    ReplyDelete
  50. Anonymous10:09 PM

    I had 2 embryos transfered and I do my HPT tomorrow (day 17) all the other HPT's iv done recently have either been negative or had a barely visible line to the eye!! I started spotting 12dpt and have been lightly bleeding ever since. I am so confused because I have lost a few clots (sorry tmi) but the colour has turned dark red yet its still not heavy! What are my chances? Please reply Dr...

    ReplyDelete
  51. The fact that you are bleeding and that the HPTs are negative is not a good sign, sorry

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  52. miracle6:50 PM

    Hello dr.

    Did a day 2 ET four days ago. 3 grade 1-(4 cell) and 2 grade 2(3 cell).
    After ET is there any feeling or symptoms i may feel to know that implantation has started? And when does implantation in my uterus really starts?

    Praise God for a successfull result!
    Awaiting your reply dr.

    Thanks!! -- miracle

    ReplyDelete
  53. No, unfortunately, there is no symptom which will tell you if and when the embryos are implanting, sorry.

    This is hardly surprising - and embryo is just a microscopic ball of cells !

    ReplyDelete
  54. i have ET after 5 day on 2nd July, On 9th July, i had some stomach pain for 3-4 hours. I called doctor, she told me to do UPT on next morning. I did on 10th .It was negative. Is this very early to do test ??

    ReplyDelete
  55. Hi dr. I am in 8th day transfer of two 3d+2d PGD, today I start bleeding, not havy but I have pain in low abdomen. Is it normal, when can I do a test?

    ReplyDelete
  56. Anonymous9:41 PM

    Hi Dr. I had 2 perfect day 5s implanted 8 days ago. I took a HPT this morning and it was negative. Is this too early or a bad sign?

    ReplyDelete
  57. Anonymous1:40 PM

    hi dr i had embryo tranfer 11 days ago i have had few signs of pregnancy so i did a 2 tests yesterday and they had faint lines and done 1 this morning and got a darker line does this mean iam pregnant 3 positive results

    ReplyDelete
  58. Anonymous12:10 AM

    Hello Dr. I had a 3 day transfer with 2 embryos done yesterday. one grade A with 8 cells and the other grade B with 9 cells. I'm not able to do my
    blood work on day 7 so I was told to have it done on day 6 instead of day 8. I think day 8 would be better but do you think day 6 could tell me if implantation occurred as opposed to day 8?

    ReplyDelete
  59. What blood work have they asked you to do ? Estrogen and progesterone levels ?

    You cannot test for implantation so soon after an embryo transfer, sorry

    ReplyDelete
  60. Anonymous8:09 PM

    Dr Dr,
    I had a 3 day embryo transfer of 2 embryos 11 days ago and had my blood test today. I have been informed that it was negative.
    Naturally I am devastated. It is it possible that I was tested too early?
    If the test result is correct how soon could I expect my period. I have beem taking Cyclogest 400mgs BD.

    Thanks

    ReplyDelete
  61. A negative beta HCG blood test 11 days after a Day 3 transfer confirms you are not pregnant, sorry

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  62. I had 1 embryo transferred on day 5 blostocysts and it was grad A it was verry good am day 11 of my 5 day transfer and I took a test day 9 and I got a positive result and am get lower bake pain and cramps is this a good

    ReplyDelete
  63. dera doctor, i had my frozen ET on 13 july 13 n my serum beta HCG on 1st aug 13 has come out to be 13,913 mIU/ml. Is it too high for day 19 post FET? i had three day 3 embyos transfered.

    ReplyDelete
  64. This is a very high HCG level and suggests you may have a multiple pregnancy


    You need to do a vaginal ultrasound scan to confirm this

    Read more at http://www.drmalpani.com/early_pregnancy_scans_atlas.htm

    ReplyDelete
  65. Anonymous7:20 PM

    Hi, doc. I have the 3 days transfer on 17 July with 3 embryo. On 28 July I start spotting and start bleeding on 30 July until today (9 Aug).
    I had took the pregnancy test on 3 Aug, 7 Aug and 9 Aug all is positive result. Now I quite worry what's wrong with me, why still bleeding? Will it affect the baby?

    ReplyDelete
  66. Can you send me your HCG levels ? Read more at www.drmalpani.com/hcg.htm

    If this is a healthy pregnancy, the levels should double every 3 days

    We look forward to helping you to have a baby !

    Dr Aniruddha Malpani, MD
    Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
    Bombay 400 005. India
    Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

    Helping you to build your family !

    PS Watch our infertility cartoon film at http://www.ivfindia.com

    Read our book, How to Have a Baby – A Guide for the Infertile Couple,
    Online at www.DrMalpani.com !

    Read my blog about improving the doctor-patient
    Relationship at http://doctorandpatient.blogspot.com/

    ReplyDelete
  67. Anonymous12:27 PM

    Hi doctor,
    I had fet with 2 grade 1 embroys on 30/07/13.Today is 11day post et but my hpt
    is -ve.Does it means cycle got failed.

    ReplyDelete
  68. Was this a Day 2 or Day 3 or Day 5 transfer ?

    ReplyDelete
  69. Anonymous4:03 AM

    i done my 1st ivf as i am nearly 39 got 1 child already i had 2 embroys transfer done a blood test on day 12 snd it came out negative . i think ivf is too expensive shoul i try again?

    ReplyDelete
  70. Anonymous4:05 AM

    it was a day 2transfer.

    ReplyDelete
  71. Anonymous6:06 PM

    Hi dr, I had a grade 1 embryo transfer on day 3 - today is 10 days past transfer and my B-hcg was 0, 7. Did we test to early?

    ReplyDelete
  72. A negative HCG 10 days after a Day 3 transfer is bad news :(

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  73. Anonymous7:20 AM

    I had a 5day embryo transfer I started to bleed on 10th day so I had a blood test witch came back negative, was the blood test to soon,its like I have my period but not as heavy as usual I also have cramps dose this mean the embryo transfer failed I cant stop crying has anyone been threw the same and still been pregnant

    ReplyDelete
  74. Anonymous2:07 AM

    I had a 5th day ET after 12 days (yesterday) HCG came out to be 562. now i am feeling severe cramps in all my body what could be the reason? m i pregnant. pain is in all body.please reply soon
    tafer

    ReplyDelete
  75. Good, this is a positive test which confirms you are pregnant.

    Please do not worry about the cramping !

    Read more at www.drmalpani.com/hcg.htm

    Repeat the test in 2 days. If this is a healthy pregnancy, it should double

    We look forward to helping you to have a baby !


    ReplyDelete
  76. Anonymous1:21 AM

    Hi Doctor,
    I had my day 3 FET on the 30th of September and starting testing on the night of 7th Oct and Have Got positive results till tonight (day 9 post transfer and day 12 post HUCOG 5000iu). 1 Grade A and 1 Grade B Embryos were transferred. Could this be an actual pregnancy or the HCG?

    ReplyDelete
  77. Hard to say. Was the FET done in a natural cycle after you ovulated ?

    Are the test results getting darker ?

    Dr Malpani

    ReplyDelete
    Replies
    1. Anonymous2:37 PM

      No it was a stimulated cycle in July and embryos were frozen on day 1 itself due to fluid in endometrial cavity. I have tested again today I.e. Day 11 of 3 day transfer and day 14 of HUCOG 5000. Still positive. They lines seem darker but could be also because the earlier ones have faded away. Please advise.

      Delete
  78. Anonymous3:14 PM

    No it was a stimulated cycle in July and embryos were frozen on day 1 itself due to fluid in endometrial cavity. I have tested again today I.e. Day 10 of 3 day transfer and day 13 of HUCOG 5000. Still positive. They lines seem darker but could be also because the earlier ones have faded away. Please advise.

    ReplyDelete
  79. Anonymous8:38 AM

    Hi Doctor just to update. Today is 11 days post transfer and 14 days post HUCOG 5000 and morning test still positive. Can HCG 5000 stay in the system for 14 days?

    ReplyDelete
  80. Anonymous4:47 PM

    Dear Dr my wife had 3 day transfer on 11/10/13 & beta was done on 24/10/13 and the result was 47.28. now she is having great nausea feeling can we expect that pregnancy is +ve

    ReplyDelete
  81. Read more at www.drmalpani.com/hcg.htm

    Repeat the test in 2 days. If this is a healthy pregnancy, it should double

    We look forward to helping you to have a baby !

    Dr Aniruddha Malpani, MD
    Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
    Bombay 400 005. India
    Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

    Helping you to build your family !

    PS Watch our infertility cartoon film at http://www.ivfindia.com

    Read our book, How to Have a Baby – A Guide for the Infertile Couple,
    Online at www.DrMalpani.com !

    Read my blog about improving the doctor-patient
    Relationship at http://doctorandpatient.blogspot.com/

    ReplyDelete
  82. Anonymous10:24 AM

    hello DR. i had 3 frozen embroy transferd on 9-Nov-2013..and on 20-Nov-2013 i did first hcg test and result is 1.5 so my doctor suggested me to do another test..so what is chances of getting pregnant..?

    ReplyDelete
  83. This is a negative HCG and confirms you are not pregnant, sorry

    Repeating the test will not help

    Can you send me more details about your IVF cycles ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  84. Anonymous7:49 PM

    Sir, is it usual to give inj choragon after embryo transfer? I had my ET on 1st march and was given choragon shots on 3rd and 6th. My test is scheduled for march 18

    ReplyDelete
  85. Some doctors do use HCG injections to provide luteal phase support after the ET in a fresh IVF cycle. These are expensive. Most use only oral estrogen and vaginal progesterone to achieve the same goal

    ReplyDelete
  86. Anonymous8:40 PM

    Hello Dr had a 5days Grade A blastocysts transfer on the 9th of April. Did a test today and came out negative . When does the embryo usually implant and whats the soonest date to do a test.. Really worried to wait these 2weeks. I am also getting some sharp pain in my stomach now and then and have a terrible back pain.

    ReplyDelete
  87. You did the test too early. You need to be patient !

    Read more at www.drmalpani.com/hcg.htm

    ReplyDelete
  88. Anonymous7:40 PM

    Dear Dr, when does a blastocysts implant in the womb after ET and after how long the hcg hormone is released

    ReplyDelete
  89. Anonymous3:02 AM

    hello doctor I had a 3day 2et 4 days ago I have other kids but my husband had the abnorm sperm shape. did a hpt today and there was a faint positive result is it too soon to be positive

    ReplyDelete
  90. Anonymous10:04 AM

    Nagative test after 7dpt of 5day embryo does it mean the embryo did not implant and the cycle was'nt successfull. Were I live they do not do beta test.

    ReplyDelete
  91. I agree this is not good news and suggests the cycle has failed. Please repeat it again after 2 days.

    Normally a HPT should be positive 14 days after egg collection.
    At this time the HCG level should be more than 100 mIU/ml in a healthy pregnancy. HPT tests are positive when the HCG level is more than 50 mIU/ml. There can be false negatives, which is why it's worth repeating it again

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    ReplyDelete
  92. A positive HPT 3 days after a ET maybe a false positive ( because of the HCG trigger injection given prior to egg collection)

    ReplyDelete
  93. Anonymous12:43 AM

    my wife underwent ivf on 16th day 28 day she got bleeding 3 drops per day immediately we reached hospital on 31st day 32nd day they tested blood hcg level,, it comes 45 means what(after 13th day of ivf)

    ReplyDelete
    Replies
    1. This is a positive HCG level but is a little low. Read more at www.drmalpani.com/hcg.htm

      Did the doctor give her an HCG injection after the transfer ? This can fool you


      Repeat the test in 2 days. If this is a healthy pregnancy, it should double

      We look forward to helping you to have a baby !

      Dr Aniruddha Malpani, MD
      Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
      Mumbai 400 005. India
      Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

      Helping you to build your family !

      PS Watch our infertility cartoon film at http://www.ivfindia.com

      Read our book, How to Have a Baby – A Guide for the Infertile Couple,
      Online at www.DrMalpani.com !

      Read my blog about improving the doctor-patient
      Relationship at http://doctorandpatient.blogspot.com/

      Delete
  94. Anonymous3:44 AM

    Hi Dr, had a 2days transfer of 6cells nd started bleeding on the 12th day called my clinic immediately and was asked to come for a test,did a blood test that came out positive but still bleeding, d Dr said I should repeat d test 4days later, can anything be done to stop d bleeding seriously worried.thanx

    ReplyDelete
  95. What was your actual beta HCG blood test result ?

    Lots of IVF clinics call a result of more than 10 mIU/ml "positive" when actually this is just a result of the HCG injection given to you during the treatment cycle.

    Read more at www.drmalpani.com/hcg.htm

    Repeat the test in 2 days. If this is a healthy pregnancy, it should double

    Can you send me more details about your IVF cycle ? What were the meds which were used for
    superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
    How many embryos were transferred ?
    What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
    Can you please send me the printed treatment summary from your IVF clinic ?

    We look forward to helping you to have a baby !

    Dr Aniruddha Malpani, MD
    Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
    Mumbai 400 005. India
    Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

    Helping you to build your family !

    PS Watch our infertility cartoon film at http://www.ivfindia.com

    Read our book, How to Have a Baby – A Guide for the Infertile Couple,
    Online at www.DrMalpani.com !

    Read my blog about improving the doctor-patient
    Relationship at http://doctorandpatient.blogspot.com/

    ReplyDelete
  96. Anonymous10:58 PM

    Hi Dr, Just did my beta hcg blood nd it came as 33 after 16 days of transfer of 3embyro nd d clinic did a blood test dt came out positive after I bled from d 12th day after d transfer to 15th day. Still feel sick nd tired like am pregnant.Does dis result look good?

    ReplyDelete
  97. This is a low HCG level and this is worrisome

    Read more at www.drmalpani.com/hcg.htm

    Repeat the test in 2 days. If this is a healthy pregnancy, it should double

    We look forward to helping you to have a baby !

    Dr Aniruddha Malpani, MD
    Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba
    Mumbai 400 005. India
    Tel: 91-22-22151065, 22151066, 2218 3270, 65527073

    Helping you to build your family !

    PS Watch our infertility cartoon film at http://www.ivfindia.com

    Read our book, How to Have a Baby – A Guide for the Infertile Couple,
    Online at www.DrMalpani.com !

    Read my blog about improving the doctor-patient
    Relationship at http://doctorandpatient.blogspot.com/

    ReplyDelete
  98. Anonymous1:19 AM

    I had 5 days transfer of 2 embryos 11 days ago can I use home pregnancy test to check? in case how truthful can be the result?

    ReplyDelete
  99. Anonymous4:26 PM

    First bhcg positve after frozen day 5 embryo. I did on 4.5 day its negative. Is it too early?

    ReplyDelete
  100. Anonymous8:28 AM

    Hi Doctor,
    Thank you for taking the time for all of us. I received a negative Beta today at 9 days post 3 day transfer of a frozen 10 cell grade 1 embryo using assisted hatching. I received conflicting instructions about when to have my blood work, but went today as it was the earlier by 5 days and I was anxious. Was this too early? I was told I was not pregnant and to stop my meds. Is there a chance I could be?

    ReplyDelete
    Replies
    1. I agree this is not good news. Do repeat the beta HCG after another 3 days please. If it's still negative, this means the cycle has failed :(

      Can you send me more details about your IVF cycles ? What were the meds which were used for
      superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
      How many embryos were transferred ?
      What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
      Can you please send me the printed treatment summary from your IVF clinic ?

      Delete
  101. Anonymous7:01 AM

    Hi dr . I am 45 and had a donor egg 5 day transfer. I am 9 days post transfer. My estrogen levels jumped up from 700 to 1007 and my progestrone was 45 to 41. I am on estrogen of 0.28 every three days and one ml of prog daily. My med level has stayed the same. Is it a possible sign of implantation that my estrogen level went up on it's own?? I go for my beta in three days . I did a hpt on day 8 and was negative . I threw out other hpt since I dont want to make myself crazy !! I look forward to hearing from you !!

    ReplyDelete
  102. There's no point in measuring estrogen and progesterone levels - they do not provide us with any useful information.

    The HCG level will tell us what's happening. Best of luck !

    ReplyDelete
  103. Hi Dr Malpani. Forgive me for asking you here in Facebook but can you please help me answer my queries. I had a FET last June 6, 2014 (5 day blastocyst) and was asked to have my blood tests check today the 17th of June. It came out negative. I was wondering, isn't it too early to have the tests done? Knowing that I am only 11 days post fet. Dr Malpani...I am confused with the way they calculate the dates. It says on the paper I have received on the day of my FET, that I need to have my blood tests approximately 14 days after embryo transfer. When you count it from the day of my FET (June 6) to the day of my blood tests earlier on (June 17), I am only 11 days post FET. Am I correct? When I spoke to my IVF Nurse, she said that they count it on the 1st day I ovulate, is that right? I was on progesterone pessaries for almost 2 weeks now and the nurse has asked me to stop using it. Please help me Dr Malpani. I am shattered beyond belief. Is it possible for me to check or use HPT on the 21st of June which is the 14th day post embryo transfer? Thank you Dr Malpani. Hoping to get answers from you.

    ReplyDelete
    Replies
    1. We do the beta HCG 14 days after egg collection. If it is less than 10 mIU/ml 14 days after egg collection, this means you are not pregnant, sorry

      If you did a Day 5 FET on 6 June, then you should consider 1 June as your day of egg collection ( conceptually)

      Can you send me more details about your IVF cycles ? What were the meds which were used for
      superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
      How many embryos were transferred ?
      What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
      Can you please send me the printed treatment summary from your IVF clinic ?

      Delete
  104. Hi Dr Malpani ,
    I got 2 embryos transferred 10 day ago. One was 8 cells embryo and second one was 4 cells embryo. I did blood test for pregnancy on 7 th day post transfer . It came negative . How reliable this test is ? Should I think cycle failed ?

    ReplyDelete
    Replies
    1. You did the test too early. You should do the HCG test 14 days after egg collection.

      Was this a Day 3 transfer ? A 4-cell embryo Day 3 has arrested and should not be transferred

      Can you send me more details about your IVF cycles? What were the meds which were used for
      superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?
      How many embryos were transferred ?
      What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm
      Can you please send me the printed treatment summary from your IVF clinic ?

      Delete

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