tag:blogger.com,1999:blog-10528990.post4898876561953299489..comments2024-03-28T16:16:27.941+05:30Comments on The IVF Specialist's Blog for IVF patients: Why do some embryos stop growing in the IVF lab ?Dr Aniruddha Malpanihttp://www.blogger.com/profile/05693466221743076739noreply@blogger.comBlogger110125tag:blogger.com,1999:blog-10528990.post-50192489185818669602018-03-14T10:56:16.580+05:302018-03-14T10:56:16.580+05:30Dear Stephanie,
This is very unusual
Was IVF done...Dear Stephanie,<br /><br />This is very unusual<br />Was IVF done ? Or was it ICSI ?<br />One possibility for this could be globozoospermia<br /><br />Can you send me more details about your IVF cycles ? <br />DO YOU HAVE PHOTOS OF YOUR EGGS ?<br /><br />You can see what eggs should look like at http://www.drmalpani.com/knowledge-center/ivf/embryos<br /> <br />Can you please send me the printed treatment summary from your IVF clinic ?<br /><br />You can email this to info@drmalpani.com<br />We look forward to helping you to have a baby !<br />Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-13389019245843235522018-03-14T02:40:44.921+05:302018-03-14T02:40:44.921+05:30Dr. Malpani,
What would your conclusion be of a 2...Dr. Malpani, <br />What would your conclusion be of a 28 year old with normal E2, AMH, FSH, etc, Severe endometriosis (deep bowel lesion on decending colon, but no endometriosis on ovaries)<br /><br />IVF Cycle 1: Antagonist protocol. Starting E2 24, ending 2500 9 day stim. 14 eggs retrieved, 7 mature, 6 fertilized, All arrested in 1-2 cell stage.<br /><br />IVF Cycle 2: Long Lupron protocol. Starting E2 <11, Ending 3864, 10 day stim. 19 Eggs retrieved, 2 Mature, 1 Fertilized, arrested at 1 cell stage.<br /><br />Both partners normal for genetic karyotyping. <br /><br />Total embryo arrest on both cycles on different protocols all in the 1-2 cell stage and low maturity rate despite most follicle ranges being in the 16-19mm range, 10,000 ui HCG trigger, and retrievals at 36 hours.<br /><br />Is endometriosis affecting egg quality this badly even though not present in ovaries, or would you suspect cytoplasm defect? <br />Is there a way to test for a cytoplasm defect.<br /><br />Would your recommendation be to pursue donor eggs or cytoplasm after 2 IVF failures on different protocols of this nature?<br /><br />Thank you very much for your time.Anonymoushttps://www.blogger.com/profile/12057711956054709879noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-86300106887218654682018-01-25T02:42:11.077+05:302018-01-25T02:42:11.077+05:30hi,we did ivf and my husband sperm count was from ...hi,we did ivf and my husband sperm count was from 18~24 millions Im 32 he is 48 years old.<br />19 eggs <br />9 embryonms <br />0 anomalies <br />we got 2 emb. transfer today.<br />we don't have any kind but I don't think your previous pregnancy has some to do with it.Anonymoushttps://www.blogger.com/profile/02082737135156741612noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-72697005890473998932017-12-22T16:54:02.520+05:302017-12-22T16:54:02.520+05:30This is standard information you can find in any m...This is standard information you can find in any medical textbook on IVF !Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-77167896376694080832017-12-22T16:52:35.414+05:302017-12-22T16:52:35.414+05:30Hard to say without more information.
Can you sen...Hard to say without more information.<br /><br />Can you send me more details about your IVF cycle ? <br />DO YOU HAVE PHOTOS OF YOUR ARRESTED EMBRYOS ?<br /><br />You can see what embryos should look like at http://www.drmalpani.com/knowledge-center/ivf/embryos<br /><br />What were the meds which were used for<br />superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood at the time of the HCG trigger ? What was the endometrial thickness ?<br /> <br />Can you please send me the printed treatment summary from your IVF clinic ?Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-77636964785450635762017-12-22T14:18:53.408+05:302017-12-22T14:18:53.408+05:30Hello Dr.. I have gone through with 2 ivf cycle ,,...Hello Dr.. I have gone through with 2 ivf cycle ,, 1st cycle August 2017 __ 7 follicles but there was no eggs I ended up with empty follicles ,, doctor said as I hv pcos and adreometrosis(which got operated on March 2017) because of that I got empty follicle , again I tried in the month of November 2017 with the same doctor initially I had 3 follicle then on the 11th day of cycle I had 5 follicle and gradually I ended up with total 8 follicle all went good , doctor retrieved 6 oocytes out of these 5 fertilized . On day 2 doctor called up and said out of 5 2 is not growing and 3 has devided in to 4 cell embryo but on day 3 , she said those 3 has arrested as this was my FET cycle so could not freeze anything .. doctor is saying it is because of egg quality and asking us to go for donor egg . Which we donot want . I want to ask if my clinic could freeze the embryos on day 2 4 cell embryo and not to wait to take them to day 3 ..please advice what should we do in this situation...thanks in advance Madhulina Deyhttps://www.blogger.com/profile/04663459183408978079noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-18932890259007385422017-11-11T21:04:14.339+05:302017-11-11T21:04:14.339+05:30Hi Dr. Malpani,
Your article was very informativ...Hi Dr. Malpani, <br /><br />Your article was very informative! May I know what were the sources or citations to this article? I would like to read further on the papers. <br /><br />Thanks!<br />Esthernoreply@blogger.comtag:blogger.com,1999:blog-10528990.post-78970888255727769112017-10-22T16:58:53.310+05:302017-10-22T16:58:53.310+05:30Hi Doctor,
I am 32yrs and my husband is 35yrs. M...Hi Doctor,<br /><br /> I am 32yrs and my husband is 35yrs. My AMH is 1.63.And my husband low count and motility. I had 1 Ivf cycle. During the cycle I had 4matured eggs, all 4 fertilized with Icsi, till day 3 all looked good but after that all got arrested and there was no transfer. Is the pattern going to repeat if we repeat the cycle? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-10528990.post-25726422484960797282017-09-04T23:57:38.420+05:302017-09-04T23:57:38.420+05:30Can you send me more details about your IVF cycle ...Can you send me more details about your IVF cycle ? <br />DO YOU HAVE PHOTOS OF YOUR EMBRYOS ?<br /><br />You can see what embryos should look like at http://www.drmalpani.com/knowledge-center/ivf/embryos<br /><br />What were the meds which were used for<br />superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood at the time of the HCG trigger ? What was the endometrial thickness ?<br /> <br />Can you please send me the printed treatment summary from your IVF clinic ?<br /><br /><br />Your low AMH level ( www.drmalpani.com/knowledge-center/infertility-testing/amh) <br />Suggests you have poor ovarian reserve .<br /><br />You can read more about this at http://www.drmalpani.com/knowledge-center/the-infertile-woman/oopause<br /><br />Can you please test your antral follicle count by doing a vaginal ultrasound scan ? Read more at http://www.drmalpani.com/knowledge-center/articles/afc<br /><br /><br /><br />IVF with aggressive superovulation would be your best option as it would maximize your chances of getting pregnant quickly and help you make the most of the eggs you have left<br /><br />Treatment takes about 20 days. Should I send you the treatment plan ?<br /><br />Meanwhile, you can take the following supplements to improve your ovarian reserve.<br /> <br />1.Yoga<br />2. Acupuncture<br />3. DHEA, 25mg thrice a day. <br />4. Wheat germ oil, 1 capsure daily<br />5. Cholecalciferol ( Vit D) , 60000 IU, once a week for 8 weeks. This is a powder available in a sachet<br /><br />Taking treatment at a world-class clinic will maximise your chances of success and give you peace of mind you did your best !<br /><br />Treatment can be expensive, but a baby is priceless. <br /><br />Plan B would to consider natural cycle IVF. Read more at www.drmalpani.com/knowledge-center/articles/natural-cycle-ivf<br /><br />Plan C would be to use donor eggs, if you are willing to consider this option<br /><br />This has a much higher success rate<br /><br />You can talk to some of our patients by email at http://www.drmalpani.com/success-stories.htm<br /><br /><br />We look forward to helping you to have a baby !<br /> <br />Dr Aniruddha Malpani, MD<br />Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba<br />Mumbai 400 005. India<br /><br />Clinic Mobile: 9867441589 <br /><br />Tel: 91-22-22151065, 22151066, 2218 3270, 65527073<br /><br />Helping you to build your family !<br /><br />You can add a google review for us at https://plus.google.com/102706636605134081909/about<br /><br />My Facebook page is at https://www.facebook.com/aniruddha.malpani<br /><br />You can follow me on twitter at https://twitter.com/drmalpani<br /><br />Watch our infertility cartoon film at http://www.ivfindia.com<br /><br />Read our book, How to Have a Baby - A Guide for the Infertile Couple,<br />online at www.DrMalpani.com !<br /><br />Read my blog about improving the doctor-patient <br />relationship at http://blog.drmalpani.com <br /><br /><br /><br /><br /><br /><br /><br />Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-40378262992651783012017-09-04T23:56:36.477+05:302017-09-04T23:56:36.477+05:30Yes, you should be worried. Grade C embryos have a...Yes, you should be worried. Grade C embryos have a very poor chance of implanting<br /><br />Do you have photos of your embryos ? How many cells are they ?<br />You can see what embryos should look like at www.drmalpani.com/knowledge-center/ivf/embryos<br /><br />I don't think your doctor did a good job with superovulating you.<br /><br />This is a common problem with PCO patients. Doctors are so scared of<br />OHSS, that they end up mistiming the HCG injection, as a result of which they<br />get many eggs but poor quality embryos.<br /><br />We have extensive experience in doing IVF for PCOD patients,<br />and our pregnancy rates are better than 48% per cycle for PCOD patients.<br /><br /><br />You can read more about how we treat PCOD at<br />http://www.drmalpani.com/knowledge-center/the-infertile-woman/how-to-manage-your-pcod<br /><br />Taking treatment at a world-class clinic will maximise your chances of success and give you peace of mind you did your best !<br /><br /><br />We look forward to helping you to have a baby !<br /><br />Dr Aniruddha Malpani, MD<br />Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba<br />Mumbai 400 005. India<br /><br />Clinic Mobile: 9867441589 <br /><br />Tel: 91-22-22151065, 22151066, 2218 3270, 65527073<br /><br />Helping you to build your family !<br /><br />You can add a google review for us at https://plus.google.com/102706636605134081909/about<br /><br />My Facebook page is at https://www.facebook.com/aniruddha.malpani<br /><br />You can follow me on twitter at https://twitter.com/drmalpani<br /><br />Watch our infertility cartoon film at http://www.ivfindia.com<br /><br />Read our book, How to Have a Baby - A Guide for the Infertile Couple,<br />online at www.DrMalpani.com !<br /><br />Read my blog about improving the doctor-patient <br />relationship at http://blog.drmalpani.com <br /><br /><br />Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-14430297502163473152017-09-04T13:26:13.900+05:302017-09-04T13:26:13.900+05:30Hi Dr.Malpani.
My Wife age is 27 & all report...Hi Dr.Malpani.<br /><br />My Wife age is 27 & all reports are normal we are doing 1st Cycle of IVF , 22 Egg has been retrieved & after day 3 there are 4 Embryos with C Grade as per our RE & further after day 5 they will confirm about more embryos to Freez so is it good to transfer grade C embryos & what are the chances of pregnancy for C Grade Embryos.<br /><br />I am little worried about this.Anonymoushttps://www.blogger.com/profile/02868111178405862718noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-75280493655070852812017-08-17T00:10:11.225+05:302017-08-17T00:10:11.225+05:30Hi, I am 34 husband 37 yrs old. I have low amh 0.9...Hi, I am 34 husband 37 yrs old. I have low amh 0.9 and taking Tab-eltroxin100. I went through my first ivf ( short protocol) resulting 3 embryos of grade 2 quality. <br />Was given 2 options 1: one more stimulation( long protocol) to optomize my chances.<br />2: frozen embryo transfer after a month.<br />Am confused what to do now. Kindly help and adviseAnonymoushttps://www.blogger.com/profile/04590996679113721482noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-17165299731441815382017-06-16T07:52:29.240+05:302017-06-16T07:52:29.240+05:30You can email me at info@drmalpani.comYou can email me at info@drmalpani.comDr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-69120790336315090962017-06-16T05:37:21.741+05:302017-06-16T05:37:21.741+05:30Hi Dr. Malpani,
I do not have all the information...Hi Dr. Malpani,<br /><br />I do not have all the information you need because it just happened, but I will obtain that shortly to get you. <br /><br />Here is what I can answer:<br /><br />Can you send me more details about your IVF cycles ? This was my first IVF cycle and we did ICSI<br />DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? I do not yet.<br /><br /><br /><br />What were the meds which were used for<br />superivulation? 3 weeks of BC, followed by 10 days of Lupron. Continued 5 units of Lupron throughout stimulation. Started with 150 units follistim for 4 days, then dropped that to 75 units and added in 75 units of menopur, we kept lowering follistim from there as I kept going in and out of range of estrogen being too high. Stimmed for 11 days and triggered with 5000 units of HCG.<br /><br /> How many follicles did you grow ? 21<br />How many eggs were collected ? 19 What was the E2 ( estradiol) level in the blood at the time of the HCG trigger ? I am unsure of this.<br /><br />What was the endometrial thickness ? I believe around 11.4<br />What was the embryo quality ? Again unsure because we still haven't been given much information besides that they looked great on Day 2 so planned to do a day 5 transfer. When they called to cancel the first thing mentioned is that ours were put in the best incubator and other embryos that went in at the same time as ours were developing normally. I believe our doctor mentioned they really stopped doing anything by day 3. And of the 19 eggs retrieved, 15 mature, 12 fertilized and 12 still growing by day 2. <br /><br />Can you please send me the printed treatment summary from your IVF clinic ? I will try to get that. Where should I send it to? <br /><br />Do you think this could be an egg quality issue? <br /><br />Again any advice you give me, would be greatly appreciated. Thank you!Bwig1010https://www.blogger.com/profile/08927447069922617992noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-86705264741816238172017-06-14T08:00:00.326+05:302017-06-14T08:00:00.326+05:30I need more information to be able to provide you ...I need more information to be able to provide you with intelligent advise.<br /><br />Can you send me more details about your IVF cycles ? <br />DO YOU HAVE PHOTOS OF YOUR EMBRYOS ?<br /><br />You can see what embryos should look like at http://www.drmalpani.com/knowledge-center/ivf/embryos<br /><br />What were the meds which were used for<br />superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood at the time of the HCG trigger ? What was the endometrial thickness ?<br />What was the embryo quality ? <br />Can you please send me the printed treatment summary from your IVF clinic ?Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-29224972906863333302017-06-14T07:59:17.937+05:302017-06-14T07:59:17.937+05:30I agree this is frustrating.
I believe the geneti...I agree this is frustrating. <br />I believe the genetic testing is useless - it does not provide us with useful actionable information.<br />Read more at https://www.drmalpani.com/articles/sperm-dna-fragmentation-assessment<br />I need more information to be able to provide you with intelligent advise.<br />When did the embryos arrest ? On which day ?<br />Can you send me more details about your IVF cycles ? <br />DO YOU HAVE PHOTOS OF YOUR EMBRYOS ?<br /><br />You can see what embryos should look like at http://www.drmalpani.com/knowledge-center/ivf/embryos<br /><br />What were the meds which were used for<br />superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood at the time of the HCG trigger ? What was the endometrial thickness ?<br />What was the embryo quality ? <br />Can you please send me the printed treatment summary from your IVF clinic ?Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-56276753981816140702017-06-14T04:51:24.671+05:302017-06-14T04:51:24.671+05:30Hi Dr. Malpani,
On Friday my husband and I recei...Hi Dr. Malpani,<br /><br /> On Friday my husband and I received a call on our way to our transfer that all 12 of our embryos had arrested and we had to cancel the transfer. I'm trying to wrap my head around this as I only know one other person that it has happened to, which happens to be my sister. She actually ended up having two babies naturally so that gives me hope. <br /><br /> However, I keep trying to find "an answer" for what possibly could have gone wrong between day three and five. Our clinic prefers to take you to the blastocyte stage if the embryos look good and based on reputation they typically do a good job of this. <br /><br /> Background info on us. We are both 33 years old and have unexplained infertility. We are personal trainers so they did think the reason for us not getting pregnant on our own had been from my body fat being too low. My husband's numbers have always been great with 95% motility. <br /><br /> For this IVF cycle they retrieved 19 eggs, 15 mature and 12 fertilized with icsi. However, they did only trigger me with 5000 units of hCG because I was at risk of developing 0HSS.<br /><br /> They are now suggesting we both get genetic tsetong done as well as having my husband do DNA fragmentation testing. <br /><br /> Any thoughts on how to move forward or other information I should be getting from my doctor? Bwig1010https://www.blogger.com/profile/08927447069922617992noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-6856089482899778382017-06-13T21:12:03.219+05:302017-06-13T21:12:03.219+05:30hello sir,
this is my 2ivf cycle and FET transfer ...hello sir,<br />this is my 2ivf cycle and FET transfer with one morula stage and one blastocyst..what is my chances of success ?<br />also my AMH is 1.4Anonymoushttps://www.blogger.com/profile/14311785885076904512noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-10386589227659817802017-05-11T14:57:38.176+05:302017-05-11T14:57:38.176+05:30Dear Rebecca,
I agree this is frustrating.
The f...Dear Rebecca,<br /><br />I agree this is frustrating.<br /><br />The fact that she produced so many eggs suggests she has PCOD; and this could explain the high percentage of chromosomal abnormality in her embryos<br /><br />You can read more about PCOD at <br />http://www.drmalpani.com/knowledge-center/the-infertile-woman/how-to-manage-your-pcodDr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-80553949957753186922017-05-11T14:27:11.440+05:302017-05-11T14:27:11.440+05:30Hi Dr Malpini,
I recently did an egg donation cyc...Hi Dr Malpini,<br /><br />I recently did an egg donation cycle with a 32 year old donor. She was a proven donor from my fertility clinic, and had done 2 previous cycles in the past 2 years. Both cycles the couples got 13 embryos each (blastocysts day 5). Her second cycle 12 months ago produced a live birth. <br /><br />My cycle was a shared cycle; the other recipient was a frozen donor egg bank. She produced 32 eggs which were split evenly. So out of the 16 eggs, 10 fertilised. On day 3 we had 7 embryos, but by day 5/6 we only had 3 embryos. We did PGS on the 3 embryos and they all came back chromosomally abnormal (cause was maternal). Do you think the fact we didn't have any viable embryos was due to the donor's age? Or lab environment, embryologists etc? My husband's sperm sample was very good, we've never had an issue with that, plus we did ICSI. <br /><br />I do wonder whether the frozen egg bank received all of the good eggs. Do you know how the lab splits them regarding their viability? <br /><br />Thank you in advance.<br /><br />Rebecca Rebshttps://www.blogger.com/profile/17804530951796329515noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-89721805542944060932017-03-11T11:19:45.710+05:302017-03-11T11:19:45.710+05:30No, there's no need for any further testing
T...No, there's no need for any further testing<br /><br />The fact you have conceived in the past ( even though you did miscarry) means your chances<br />of having a healthy baby are excellent, so please don't get disheartened !Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-65617335496057784432017-03-11T11:19:20.021+05:302017-03-11T11:19:20.021+05:30Any doctor who blames "poor quality" spe...Any doctor who blames "poor quality" sperm for failure of an ICSI cycle is a poor quality doctor<br /><br />Please find a better doctor !Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-4379864864917935392017-03-11T11:17:40.351+05:302017-03-11T11:17:40.351+05:30This suggests your IVF lab is not a good quality l...This suggests your IVF lab is not a good quality lab. In a good clinic, survival rates after thawing vitrified embryos are nearly 100%Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-56183965267129594632017-03-11T11:17:01.777+05:302017-03-11T11:17:01.777+05:30You seem to have received very poor quality care, ...You seem to have received very poor quality care, sorry<br /><br />Where are the photos of your embryos ? <br /><br />This is not correct. You have a legal right to your medical records - every hospital has to provide them by law ! Please make a request for this in writing.<br /><br />The only tangible product an IVF clinic can deliver is embryos ! All good clinics provide embryo photos proactively and routinely<br /><br />Any clinic which does not provide embryo photos is a poor quality clinic.<br /><br />Please find a better clinic if you want to maximise your chances of success - one which does only blastocyst transfers and provides embryo photos routinely to all patients<br /><br />Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-63852602954130326672017-03-11T11:16:13.026+05:302017-03-11T11:16:13.026+05:30You seem to be a poor ovarian responder, and the c...You seem to be a poor ovarian responder, and the commonest reason for embryo arrest in patients with poor ovarian reserve is suboptimal egg qualityDr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.com