tag:blogger.com,1999:blog-10528990.post3947623331462445907..comments2024-03-28T16:16:27.941+05:30Comments on The IVF Specialist's Blog for IVF patients: The smoke and mirrors behind HLA matching and NK cells activity assay – the “reason” and “cure” for unexplained implantation failure!Dr Aniruddha Malpanihttp://www.blogger.com/profile/05693466221743076739noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-10528990.post-89165100236026859562016-09-13T15:39:09.574+05:302016-09-13T15:39:09.574+05:30Marvelous! very well explained.Thank You So much S...Marvelous! very well explained.Thank You So much SirAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-10528990.post-22664256208914533512015-12-23T11:56:12.725+05:302015-12-23T11:56:12.725+05:30Dear Rashmi,
Do a complete workup before starting...Dear Rashmi,<br /><br />Do a complete workup before starting treatment haphazardly.<br /><br />You need to do ALL the following simple medical tests:<br /><br />semen analysis for your husband ( to check his sperm count and motility).<br />Read more at http://www.drmalpani.com/knowledge-center/resources/book/chapter4b<br /><br />blood tests for you for the following reproductive hormones - FSH ( follicle-stimulating hormone),LH ( luteinising hormone),PRL ( prolactin) , AMH ( antiMullerian hormone) and TSH ( thyroid stimulating hormone) on Day 3 of your cycle, ( to check the quality of your eggs). Do this from a reliable lab such as SRL ( www.srl.in). Day 1 = Day the period starts.<br /><br />HSG ( hysterosalpingogram, X-ray of the uterus and tubes, http://www.drmalpani.com/knowledge-center/articles/hysterosalpingogram) on Day 8 of your cycle ( to confirm<br />your fallopian tubes are open); <br /><br />The vaginal ultrasound scan on Day 10-11 should check for the following. a. ovarian volume b. antral follicle count c. uterus morphology d. endometrial thickness and texture<br /><br />Please send me ALL the detailed test results and medical reports . You can scan them in as a single doc or pdf file and email them to me.<br /><br />Please send me all the results together, rather than piecemeal, so I can interpret them intelligently<br /><br />With these test results, we can determine what medical problems are causing your<br />infertility.<br /><br />If there is a problem, then we can treat it !<br /><br />Taking treatment at a world-class clinic will maximise your chances of success and give you peace of mind you did your best !<br /><br />You can talk to some of our patients by email at http://www.drmalpani.com/success-stories.htm<br /><br />We look forward to helping you to have a baby !<br /><br />Regards,<br /><br />Dr Aniruddha Malpani, MD<br />Malpani Infertility Clinic, Jamuna Sagar, SBS Road, Colaba<br />Mumbai 400 005. India<br /><br />Clinic Mobile: 9867441589 <br /><br />Tel: 91-22-22151065, 22151066, 2218 3270, 65527073<br /><br />Helping you to build your family !<br /><br />You can add a google review for us at https://plus.google.com/102706636605134081909/about<br /><br />My Facebook page is at https://www.facebook.com/aniruddha.malpani<br /><br />You can follow me on twitter at https://twitter.com/drmalpani<br /><br />Watch our infertility cartoon film at http://www.ivfindia.com<br /><br />Read our book, How to Have a Baby - A Guide for the Infertile Couple,<br />online at www.DrMalpani.com !<br /><br />Read my blog about improving the doctor-patient <br />relationship at http://blog.drmalpani.com <br /><br />Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-6169802238840387202015-12-23T11:38:25.232+05:302015-12-23T11:38:25.232+05:30I am 32 and husband 33.. Married for 2 years and a...I am 32 and husband 33.. Married for 2 years and actively trying we have had three unsuccessful iui and two unsuccessful icsi ivf attempts.. Husband diagnosed with teratozoospermia first ivf attempt no embryo formed from five eggs and we did half donor half husband sperm for second time.. This time we had three embryos frozen and did FET in dec.. Which failed.. <br />I am married for second time and did face infertility during first marraige as well but we never went for any treatment.. I have done all standard tests and are normal.. I ovulate regularly and have normal 28 day cycle. I am taking 100 mcg eltroxin for hypothyroidism. What are your thoughts on the further treatment plan we should opt for? Anonymoushttps://www.blogger.com/profile/08790838610816467324noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-21890549565030636432014-09-15T01:33:40.977+05:302014-09-15T01:33:40.977+05:30I was give 225 IU of Gonal F daily starting day 2 ...I was give 225 IU of Gonal F daily starting day 2 of my cycle. AMH was high but i remember i didnt have a rise of LH over FSH. E2 was measured twice. The first was on day 2 of my cycle and the second was before egg retreival. I would have to go back to my discharge summary to get the results but I remember (and even the doctor commented) that they were within normal and good range. I grew 16 follicules and 16 eggs were retreived, 13 were mature enough but only 8 got fertilized. 1 embryo was returned at blastocyct stage. Endometrium thickness was 9mm. Was given antibiotic for 5 days after egg retreival and cyclogest 400 twice daily and asked to test on day 9. Biochemical pregnancy was acheived and ended by week 5. Embryo was grade A and yes I have a picture of the embryo on a CD. The previous 2 IVF cycles I dont remember clearly beacuse they were done 4 years ago. 2 grade A embryos were transfered in each cycle (btw the 2nd cycle did not include PGD and we had a day 3 transfere). I remember all doctors used to comment that all my tests look normal and I shouldnt have a problem conceiving! Each cycle was done in a different center and I tried my very best to chose the center wisely. All cycles used more or less the same protocol and medications and I produced almost the same number of eggs (on the cycle where we did not opt for PGD I was given a lower dose of FSH and thus I remember i had around 10 or 8 eggs retreived) except I feel that with the last trial I had more eggs not getting fertilized compared to previously. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-10528990.post-26768506540781812762014-09-14T23:52:03.239+05:302014-09-14T23:52:03.239+05:30I need more information to be able to provide you ...I need more information to be able to provide you with intelligent advise.<br /><br />Can you send me more details about your IVF cycles ? What were the meds which were used for<br />superovulation ? What was the dose used ? How many follicles did you grow ? How many eggs were collected ? What was the E2 ( estradiol) level in the blood ? What was the endometrial thickness ?<br />How many embryos were transferred ?<br />What was the embryo quality ? DO YOU HAVE PHOTOS OF YOUR EMBRYOS ? You can see what embryos should look like at http://www.drmalpani.com/embryos.htm <br />Can you please send me the printed treatment summary from your IVF clinic ?<br /><br />The fact you have conceived in the past means your chances of having a healthy baby are excellent, so please don't get disheartened !Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-9943055069144243432014-09-14T23:47:59.792+05:302014-09-14T23:47:59.792+05:30So far I have had 3 failed IVF cycles with a total...So far I have had 3 failed IVF cycles with a totally number of 5 embryos transfered. 6 IUI's and they only time i fell pregnant was spontaneously and carried to term. I need to do PGD with HLA matching because my ony child needs BMT.. why do you think I had that much failed cycles? What could u possibly do next. Im only 31 with PCOD.. I still have hope of conceiving I only need to do it so quick for the sake of my childAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-10528990.post-13893675293369650732014-09-14T11:21:51.420+05:302014-09-14T11:21:51.420+05:30You are falling prey to a very common fallacy whic...You are falling prey to a very common fallacy which plagues IVF today. PGD only allows us to check that the embryo's chromosomes are normal, that's all. It does not mean that the embryo is genetically normal. Lots of embryos with lethal genetic defects ( which is the commonest cause of failed implantation and miscarriages) will be normal chromosomally. Your conclusion that because PGD was normal means "there is nothing wrong" with the embryo is completely faulty. There are lots of success stories with lots of different interventions - but most of them are unproven and wasteful.Dr Aniruddha Malpanihttps://www.blogger.com/profile/05693466221743076739noreply@blogger.comtag:blogger.com,1999:blog-10528990.post-31263819760869030752014-09-13T23:17:32.706+05:302014-09-13T23:17:32.706+05:30I cant thank you enough for this article.. you hav...I cant thank you enough for this article.. you have no idea how depressed I felt after reading Dr. Sher's blog but I kept researching and reading more trying to better understand this untill I came into your blog. However I still have questions in regards to immunologic implantation dysfunction, i have had repeated biochemical pregnancies following IVF with PGD and PGS. So i know for sure there is nothing wrong with the embryo, but cant help but wonder why does the pregnancy end so fast? And could it really be because of immunological issues or of luteal phase dysfunction (endometrial function test). I have read in the news and many stories of ivf success after intralipid infusions along with steroids and heparin.. what are your thoughts on this? Should I give it a try?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-10528990.post-23687637943538370662014-04-24T15:00:08.950+05:302014-04-24T15:00:08.950+05:30This is a very thoughtful, informative article. Th...This is a very thoughtful, informative article. Thanks for sharing it!protein tozuhttp://www.masterprotein.comnoreply@blogger.com