Wednesday, March 30, 2011

Bureaucracy cannot practise medicine - trying to managing healthcare and doctors

Everyone is worried about the escalating costs of providing medical care. Many solutions to this problem have been based on the premise that the reason medical care is a mess today is because health care delivery is not being properly "managed". The siren song is that if we can "manage" healthcare delivery properly, we will be able to provide better medical care to more patients at a lower cost !

Management seems to have become the panacea to all ills - and it's a very tempting idea ! After all, isn't it obvious that managing something can just help to make it more efficient and effective ?

Sadly, in real life, this is not true. In order to manage healthcare, we need managers who have special training and expertise in management; and then inject them into hospitals to manage doctors . All this ends up creating is an additional layer of people between doctors and patients - a layer which has no medical expertise - and which just adds to costs and paperwork !

Interestingly, this is as true in education as it is in medicine. A great book by Philip Howard called Life Without Lawyers has a thought-provoking chapter titled - Bureaucracy Cannot Teach ( from which I've lifted the title of my post).

He writes - " All these reforms have been based on an unspoken assumption: that better organisation is the key to fixing whatever ails schools. The theory is that by imposing more organisational requirements - better teacher credentials, more legal rights, detailed curricula, the pressure of tests - schools will get better. That's the theory. The effect, however, is to remove the freedom needed to succeed at any aspect of teachers' responsibilities - how they teach, how they relate to students, and how they coordinate their goals with administrators."

Applied to healthcare, this would read, He writes - " All these reforms have been based on an unspoken assumption: that better organisation is the key to fixing whatever ails hospitals. The theory is that by imposing more organisational requirements - better doctor credentials, more guidelines, more legal rights for patients, detailed medical curricula, testing for performance - hospitals will get better. That's the theory. The effect, however, is to remove the freedom needed to succeed at any aspect of doctors' responsibilities - how they treat , how they relate to patients , and how they coordinate their goals with administrators."

Bureaucracy often ends up smothering teachers - and doctors as well ! When we try to manage something, we often end up mismanaging it !

Most management principles are simple applied common sense - and rather than try to have more managers, it would make much more sense to teach doctors basic managerial skills, so they can do a better job managing their patients - and themselves !
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Tuesday, March 29, 2011

Mobile health and dumb phones

Given the fact that practically every one on this planet will soon have their own personal mobile phone, it's a very tantalising goal to be able to use this personal phone to help people improve their personal health ! Mobile phones are personal; private and ubiquitous and can be very powerful tools ! Mhealth has become a "hot area" today - and there are many clever applications available which help phones to become health monitoring devises.

However, most of these apps have been developed in the West and they are designed for "smartphones". They are cool and fun to play with but we desperately need clever developers to produce apps for dumb phones - the kind of phones the billion who are at the "bottom of the pyramid" have to use daily. This is a much bigger challenge - but the results can be earth-shaking !
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Monday, March 28, 2011

What medicine can teach economists and marketeers !

There's a lot doctors can learn from other professionals - and there's a lot doctors can teach others as well !

An interesting "recent" innovation in economics is the introduction of "controlled trials" to determine the true impact of interventions to help alleviate poverty. Common sense would suggest that giving the poor loans will them help to turn around their lives - but in reality, this is not what usually happens. The road to hell is paved with good intentions, and "aid" can often end up killing initiative ; fueling waste and corruption; and breeding dependence ! Handouts don't always work well - and it's easy to waste a lot of money very quickly ! The only way to find out what works and what does not work is to perform experiments in the field - something which doctors are very good at ! Innovations are a part and parcel of medicine - but which ones are really useful ? And which ones aren't ? Doctors are very good at figuring this out because they've been doing this for so many years - and the staple technique we use to do so is called a controlled clinical trial. Economists are now adding these to their armamentarium to judge how valuable field interventions are , so they have data to analyse impacts, rather than just having to depend upon their intuition !

Interestingly, marketeers do this all the time as well. They need to figure out which ads work; which don't; and which provide the most bang for their buck. In marketing, a randomised trial is called split A/B testing !

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Sunday, March 27, 2011

Physicians and the Moral Obligation to Create Content

Dr Vartabedian has an interesting blogpost. " I was thumbing through Seth Godin’s Poke the Box and stumbled on this quote. I couldn’t help but put it in the context of physicians and their obligation to make content:

I hope we can agree that there’s a moral obligation to be honest, to treat people with dignity and respect, and to help those in need.

I wonder if there’s also a moral obligation to start.

I believe there is. I believe that if you’ve got the platform and the ability to make a difference, then this goes beyond “should” and reaches the level of “must.” You must make a difference or you squander the opportunity. Wasting the opportunity both degrades your own ability to contribute and, more urgently, takes something away from the rest of us."

Some old-fashioned doctors still think it's unethical for doctors to have a website. They fell this is like advertising - and not something which medical professionals should do !

It's interesting to see Dr Vartabedian's viewpoint, which I agree with completely ! The word doctor is derived from the word "docere" = to teach; and I feel doctors have an ethical obligation to do so. They need to teach not just the next generation of doctors, but their patients as well. The internet is a very powerful means of teaching and doctors who do not use it to educate their patients are doing a disservice - to themselves, the medical profession; and their patients !


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What infertile couples go through - and how IVF can help !

Saturday, March 26, 2011

Patient educational materials on cancer from JASCAP and HELP !

http://www.scribd.com/doc/51531195/What-You-Need-To-Know-About-Cancer-with-Dictionary

http://www.scribd.com/doc/51531208/Acute-Lymphoblastic-Leukaemia

http://www.scribd.com/doc/51531210/Acute-Myeloblastic-Leukaemia

http://www.scribd.com/doc/51531247/Bladder-Cancer

http://www.scribd.com/doc/51531266/Brain-Tumours

http://www.scribd.com/doc/51531292/Breast-Cancer-Primary

http://www.scribd.com/doc/51531335/Breast-Cancer-Secondary

http://www.scribd.com/doc/51531358/Cancer-of-Larynx

http://www.scribd.com/doc/51531954/Cancer-of-the-vulva

http://www.scribd.com/doc/51531969/Cancer-of-the-womb-uterus

http://www.scribd.com/doc/51531998/Chemotherapy

http://www.scribd.com/doc/51532012/Chronic-Myelogeneous-Leukaemia

http://www.scribd.com/doc/51531491 - Hodgkins Lymphoma

http://www.scribd.com/doc/51532061/Colon-and-Rectal-Cancer

http://www.scribd.com/doc/51532069/Diet-and-the-Cancer-Patient

http://www.scribd.com/doc/51532544/Testicular-Cancer- Testicular Cancer

http://www.scribd.com/doc/51532286/Myeloma-10-Sept-2009

http://www.scribd.com/doc/51532270/Malignant-melanoma

http://www.scribd.com/doc/51532230/Lung-Cancer

http://www.scribd.com/doc/51532193/Liver-Cancer

http://www.scribd.com/doc/51532182/Kidney-cancer

http://www.scribd.com/doc/51532148/Kaposi-s-sarcoma

http://www.scribd.com/doc/51532126/Head-and-Neck-Cancers

http://www.scribd.com/doc/51532246/Lymphoedema

http://www.scribd.com/doc/51532534/Stomach-Cancer

http://www.scribd.com/doc/51532516/Stem-cell-and-bone-marrow-transplants

http://www.scribd.com/doc/51532509/Soft-tissue-sarcomas

http://www.scribd.com/doc/51532502/Skin-Cancer

http://www.scribd.com/doc/51532493/Sexuality-and-Cancer

http://www.scribd.com/doc/51532487/Seondary-Bone-Cancer

http://www.scribd.com/doc/51532473/Radiotherapy

http://www.scribd.com/doc/51532467/Prostate-Cancer

http://www.scribd.com/doc/51532423/Primary-Bone-Cancer

http://www.scribd.com/doc/51532388/Pancreatic-Cancer

http://www.scribd.com/doc/51532372/Ovarian-Cancer

http://www.scribd.com/doc/51532330/Oesophageal-Cancer

http://www.scribd.com/doc/51532297/Non-Hodgkin-Lymphoma

How many weeks pregnant am I ?


Many IVF patients get very confused about how the doctor calculates the age of their pregnancy
( = gestational age, in medical jargon). Logically, shouldn't it be from the day of the embryo transfer ? After all, it's only after the embryos are transferred that a woman can be considered to be pregnant !

However, doctors are not always logical, and we usually use the menstrual age when talking about the length of the pregnancy. This is because obstetricians usually see women who have got pregnant after having sex in their bedroom. Very few of them will know the exact date they ovulated , which is why we use the menstrual age in clinical practise. This does not change just because you have had an IVF pregnancy - the clinical rules remain the same !

This creates a lot of confusion in patient's minds - especially when they are trying to make sense of their ultrasound scan results or their HCG levels.

Remember that your OB is always talking about the menstrual age - not the age of the
embryo ! This is purely for clinical convenience and is a well-accepted universal convention.

So how do you convert the date of embryo transfer to menstrual age. This is very simple ! The key reproductive event you need to focus on is ovulation ! It makes much more sense to talk about the pregnancy in terms of DPO ( days post ovulation), rather than the menstrual age or the day of the embryo transfer. This is because we can use this landmark for all situations
( including IUI pregnancies; and for Day 3 embryo transfers and Day 5 embryo transfers as
well !)

Since every IVF patient knows the date they ovulated ( = the day of egg collection), it's easy to calculate your menstrual age. Just subtract 14 from your date of ovulation. This is your
" corrected LMP" ( last menstrual period) .

( Corrected) LMP = Date of egg collection minus 14

The reason we do this is simple - it's because text books assume the follicular phase is exactly 14 days ! Once you know your corrected LMP, it's then easy to use this as the anchor, based on which your OB can calculate your gestational age.

This means that the menstrual age will always be 14 days more than the actual age of the embryo.

Confused ? Let's look at an example.

Let's suppose your LMP was 5 Jan; and your egg collection was done on 24 Jan ( let's assume you took a long time to grow eggs); and your embryo transfer was done on 29 Jan ( Day 5 transfer). The HCG pregnancy test will be usually done about 14 days post ovulation ( DPO), which is 7 Feb. If it's positive - say 120 mIU/ml, the doctor will confirm you are pregnant ! This means that even though you are only 14 DPO ( and your embryo's age is only 14 days ) , he will calculate your corrected LMP as 10 Jan ( date of ovulation , 24 Jan, minus 14 days) - which means your clinical gestational age ( or menstrual age) will become 4 weeks ( 28 days) ! Once you understand this " 2 week gap" and the rationale behind it , you'll find it much easier to date your pregnancy !
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Friday, March 25, 2011

Black money

There's a lot of talk about how much Indian black money is stashed away in Swiss banks.

The only difference between black money and white money seems to be whether or not taxes have been paid on this . I used to be very proud of the fact that I am an honest citizen and that we pay our taxes, but given how the Indian government misuses the revenue it collects, I am not sure any more that paying taxes is such a big deal.

I feel the difference between good money and bad money is whether the money is being used or not. Good money is circulated - and bad money is locked up in safes !

Teaching billionaires to be philanthropic

The Indian newspapers are full of laudatory articles about how Warren Buffett is teaching Indian billionaires to be generous.

I think this is flawed. The only kind of people who become billionaires are the ones who have a very strong acquisitive streak - and these are not usually the kind of people who are willing to part with their money.

I know Gates and Buffett get a lot of good press about donating money - but when you consider their net worth, the amount they give away is a pittance. Thus, if Gates' net worth is 50 billion dollars, and he wants to keep the corpus of his trust fund intact so that it continues to function even after his death, he should be giving away at least 5 billion dollars a year !

Thursday, March 24, 2011

Why EMRs perform badly !

" Four years after a pilot project to computerise services at state-run medical colleges and hospitals was launched, the state Medical Education Department has done a rethink and no longer considers the idea “feasible”.

This is typically what happens when these big buck projects are implemented with a Top-Down approach. A bureaucrat with a lot of money to burn decides this is a clever idea and tries to put it into practise. ( Because there's lots of money involved, it's easy to grease palms) . The results are very predictable - the project flops because there's no buy in from doctors . The project is then scrapped - and the technology gets a bad name ! It's not the technology or the idea which is flawed - it's just the way it was implemented. However, this will set EMR projects back by at least a decade, as everyone will now believe that the failure of this project " proves that EMRs do not work in India "



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Infertility - the man's perspective ! An IVF success story

We were a happy carefree couple, enjoying our freedom to do things that we liked, for the first four years of our marriage. And then when we finally thought of starting a family…. It didn’t happen for another year and we were happy childfree couple. Couldn’t figure out initially what can go wrong, but when we decided to do a reality check, we landed up at a neighborhood Obs&G’s clinic. She ran a few preliminary tests which didn’t point to anything in particular, prescribed few medicines for me. Six months later, the same tests were repeated again, and again. And then I was referred to a urologist for surgery for a suspected varicocele. That’s when it dawned upon us that may be we are knocking on the wrong door!

After a couple of months & a million clicks on the net, we decided to go to a specialist. The research on the net had classified us suffering from “unexplained infertility”. We landed up at Dr Malpani’s in search of explanation. Few new tests were prescribed for my wife and same old ones for me. Everything looked normal to the doc, which was a source of confidence that it would happen sooner or later. We were suggested to try IUI at our local gynec for 3 cycles. There was a hint of sadness creeping up after every unsuccessful IUI. Doubts started cropping up… Did we leave it for too late to start the family? We were back to the drawing board. Dr Malpani assured that everything was ok and he suggested IVF and we decided to go ahead. It’s to the clinic’s credit that the entire process is handled so systematically & in such an organized way that it gives you the confidence that every thing possible will be done, without going overboard,
to make it a success. The entire IVF process went as planned by the doctors and bingo…now we have graduated from being TTC couple to 12 weeks pregnant!

A BIG thanks to both Dr Aniruddha & Dr Anjali and their team!

mum.pgs@gmail.com


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Wednesday, March 23, 2011

Happy IVF patient from Mumbai !

After more than 7 years of marriage finally we had started seriously thinking about making an addition to our family, but our efforts were not yielding results. As the age factor was catching up on us, we were advised to go in for IUI treatment. After 3 failed IUI attempts, I was completely disheartened and dejected. Fortunately that's when one of our colleagues mentioned Dr. Malpani and their success story after undergoing his treatment.

We had nothing to lose, and decided to give it a shot. My work had anyway brought me to Mumbai from Bangalore and we decided to make the most of this opportunity.

Our first consultation with doctor boosted my confidence tremendously and I felt that finally I had reached the right place. The doctor put me to ease instantly. After perusing all my earlier reports, he advised me to get a couple of blood tests done. We were glad that we were not asked to repeat any of the tests done earlier. He explained the details of the entire treatment and assured us to remain positive.

One the first day of my next cycle, I visited the doctor's clinic again. Then started the routine of injections and scans. On day 9, the day of my first scan, I had gone to the clinic with a lot of hope, only to be devastated. The doctor was completely disappointed with the results as the follicular growth was well below expectations. After increased dosages of injections and regular scans the results were still not satisfactory by Day 14. It seemed to be the end of the world!

Dr. Anjali recommended that I need not lose hope and advised that we continue the round of injections for another few days. We are extremely grateful to her for instilling hope and believing that the results will improve and that there was a chance… somehow! Finally on Day 21 (exactly a week later) the doctor recommended that the follicles were now ready and we could go for egg collection.

I had thought that this cycle would be futile and we would have to wait for another cycle to try our luck, but thanks to the experience and reassurance of Dr. Anjali, we were able to utilize the current cycle as well.
After the IVF procedure, started another difficult phase of waiting for the results. Since I had 3 failed IUIs and a delayed ET in the current cycle, I was quite prepared for the worst. Finally 14 days after ET, it was time to get the blood test (BHCG) done. And lo and behold... the result was positive. My husband and me could not believe the results. I did not want to celebrate as yet. As recommended by the doctor, the tests had to be done twice again and we waited patiently. Each time the results were positive and finally, reality had sunk into me. It was unbelievable. I had finally conceived... It was something which I thought could never happen to us and we cannot thank Dr. Malpani and Dr. Anjali enough for making this dream come true for us. Now I am 4 months pregnant and hoping all goes well till the end...

We would like to emphasize the personal attention, constant assurance and the positivity that we experienced at Dr. Malpani's clinic. The staff too is very cordial, well-trained and caring. I can certainly compare my experience here with the others that I had consulted and taken treatment, and frankly there is no comparison. The Malpanis are extremely passionate in what they do, they treat every patient with equal care and patience and make each one feel important. I only wonder how they manage to do this even after so many years of practice and doing the same things over and over again. Hats off to the doctors!! I am also amazed at the responsiveness of the doctor to emails. Rest assured that you will get a reply to your email within 24 hrs, no matter how busy he is!

I would certainly recommend Dr. Malpani to everyone seeking infertility treatment anywhere in India. Please make the first visit and you will never regret!!

Technology for Doctors - smartphone-based ultrasound system

Technology for Doctors - smartphone-based ultrasound system : " Washington-based health startup, Mobisante, recently announced FDA approval of its smartphone-based MobiUS portable medical ultrasound unit. The mobile ultrasound system requires nothing more than the wand, some gel and a Windows Mobile-enabled smartphone. "

It's amazing how smart medical applications for smartphones have become !

Tuesday, March 22, 2011

59 Top Physician Blogs Worth Reading - Freelance MD Blog - Freelance MD

59 Top Physician Blogs Worth Reading - Freelance MD: "While the majority of physicians haven't exactly embraced the rise of social media, here are some of the physician thought leaders who have."

I am very pleased and proud that my blog was selected ! It's the only blog from an Indian physician on this list - why aren't more Indian doctors blogging ?

Monday, March 21, 2011

How radiation can harm your health - in Hindi !

You can read Dr Mahesh Sharma's lucid exposition on how radiation can harm your health here !

Very timely and topical in light of the all the health scares after the nuclear power tragedy in Japan.

A photo essay on how an early normal pregnancy develops

The first few weeks of an IVF pregnancy are often packed with tension ! Is all well ? Is the pregnancy developing normally ? Every minor spot of blood leads to panic - ans there's a lot of suspense when you get your HCG results and go for your ultrasound scans !

Seeing your baby's heart beat for the first time on the scan can be a very emotionally charged moment ! This photo essay by Dr Hemant Morparia shows you how a normal pregnancy evolves, as seen by ultrasound scanning, so you know what to expect !

Please remember that the weeks refer to clinical age ( as calculated from the last menstrual period, LMP) and not the actual age of the embryo !
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Donor Eggs and Egg donation

We run an active egg donation program which is a very useful treatment option for older women; women with ovarian failure; and those who have failed many IVF cycles as a result of having poor quality embryos.

While it's true that the idea of using donor eggs can be very difficult to accept, it's a treatment option which has a very high success rate ! It also offers many advantages. You get to experience pregnancy; bond with your baby; and your child will have your name on its birth certificate, so that the fact that you have used donor eggs is something which no one else needs to know. It's thanks to donor egg technology that we are now seeing a spurt of celebs who are 40+ who are giving birth to twins and triplets !

We will be happy to help you find an egg donor . We have many healthy young fertile Indian women ( all of whom are less than 30 years of age , have been medically tested for their fertility ; and screened for infectious diseases such as hepatitis and AIDS ) on our egg donor panel, who have been fully evaluated .

Saturday, March 19, 2011

Why I admire women with vaginismus who come for infertility treatment

Vaginismus is a surprisingly common sexual disorder which causes a lot of distress and low self esteem. Women with vaginismus feel inadequate and incompetent; and they cannot share their diagnosis or problem with anyone. They feel like freaks - and feel guilty that they cannot give their husband sexual pleasure.

Not only does this put a lot of stress on the marriage, the desire to have a baby can often be the last straw which breaks the camel's back ! While the urge to complete the family maybe very strong, they are petrified about the fact that they may need to seek medical attention to achieve this goal. For a woman with vaginismus, even the idea of going to a doctor can cause sleepless nights.

The fact that many gynecologists are clueless about this condition can just end up making a bad situation even worse. They will often pooh-pooh the woman's concerns; or force her to subject herself to a painful , humiliating and degrading exam which makes her feel that she was raped and puts her off going to all doctors for ever ! Many unsympathetic doctors will actually blame the woman for her problem - or advise surgery ( an obsolete operation called a Fenton's) to fix a problem which was never mechanical in the first place !

It needs lots of courage for these women to go to a doctor - and while they can be challenging to manage and need a lot of time, energy and empathy, I take my hats off to these brave women who are willing to put themselves through so much in order to have a baby !


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Friday, March 18, 2011

Please become a better patient !

Happy patients are happy with their doctors - while unhappy ones are happy to blame and criticise their doctor. Doctors seem to have become everyone's favourite whipping boys - they are greedy and just want to make lots of money; they do not have time for their patients ; and cannot communicate well.

It's very easy to blame the doctor, but this is hardly helpful ! Patients need to understand that getting good medical care requires they they establish a healthy doctor-patient partnership - and in order to do this, they need to become expert patients !

This has become surprisingly easy to do, thanks to the net. All you need to do is invest some time and energy - and if you do get lost, there are lots of people who can help, including online bulleing boards and forums; and librarians.

The rewards are well worth it - after all, if you are not part of the solution, you are part of the problem ! You cannot change your doctor's behaviour - but you can change yours ! Do not underestimate your intelligence and common sense - you have a lot at stake ! A big plus to doing so is that armed with the information, you'll be able to find a better doctor !

Taking treatment at a world-class clinic will maximise your chances of success and give you peace of mind you did your best !



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Thursday, March 17, 2011

Medicine and Technology : Doctor-Patient Interaction and Web 2.0

Medicine and Technology : Doctor-Patient Interaction and Web 2.0: "Increased patient interactivity in their own health care could bring a lot of potential benefits, many of which focus on increasing the flow of information and enabling patients.

• Bettering the information in health records by using PCHRs could lead to more accurate diagnosis and treatment.
• Rather than completely depending on the doctor for explanations of technical issues, patients could use the Internet to further their understanding.
• Giving patients more power over their own health could make them more committed to bettering their health.
• The greater exchange of information could lead to a stronger relationship between doctor and patient. Instead of spending clinical visits exchanging basic information (which would have already been conveyed by PCHR and email) the two could discuss more detailed information about the patient’s situation.

Sperm DNA fragmentation assessment: Is it really helpful?

All infertile couples know that the sperm plays a vitally important role in fertility. However, there's still a lot of confusion ! If we need only one sperm to fertilise an egg during ICSI, does the sperm count and motility really matter ? And if it does, how and why ?

The fact that the WHO has kept on changing the definition of what a normal sperm count just testifies to the fact that experts are as confused as patients are. This is especially true when we consider 3 contentious areas. While it's true that the sperm provides 50% of the child's DNA, can it be responsible for:
failed fertilisation after ICSI ?
poor qualty embryos ?
miscarriages ?

In order to drill down further into when the sperm can be responsible for reproductive problems, researchers have developed sophisticated tests to analyse whether the sperm are "normal " or not. In the past, the only tests we had available were the sperm count, motility and morphology. These are admittedly crude tests, and the hope was that newer tests which could directly check the functional status of the sperm's DNA would give us more useful information. Logically, since the man's DNA contributes half of the offspring’s genetic material , it is reasonable to assume that abnormal DNA in the form of fragmented DNA ( when excessive strand breaks are present ) may lead to derangements in the reproductive process.

Let's look at some of these tests.

The tests used for the assessment of sperm DNA integrity can be distinguished into direct and indirect. Direct assays try to detect the actual DNA breaks, while indirect assays quantify the susceptibility of sperm DNA to break after an external insult, such as acid treatment. The most commonly used direct assays are; Terminal Deoxynucleotidyl Transferase-mediated Nick End Labeling (TUNEL), Single Cell Gel Electrophoresis (COMET) and In-Situ Nick Translation (NT) assay. The most common indirect assays are; Flow flow cytometric acridine orange assay, Acridine Orange test (AO), DNA Break Detection-Fluorescence In Situ Hybridization (DBD-FISH) and Sperm Chromatin Dispertion test (SCD).

The very fact that it's such a long list is a testimony to the fact that we really do not understand what the results signify in real life. For example, breaks affecting genes in “silent” areas of the genome are unlikely to have any clinical importance, but no assay can evaluate this factor yet.

The truth is that for the present, there is no differentiation between clinically significant and insignificant fragmentation. While it's true that many studies using a variety of assays have shown statistically significant differences in sperm DNA fragmentation between fertile and infertile men, remember that these refer only to the mean or median . In reality, there is extensive overlap between the values found in fertile and infertile men.

Because these tests are so new, they've not been standardised. Clear reference values have still not been established, just adding to the confusion. Just like conventional semen parameters have been proven to be disappointing at predicting the outcome of IVF, sperm DNA fragmentation has been equally disappointing in predicting pregnancy rates after standard IVF and ICSI.

If you have poor quality embryos and your test shows you have increased sperm DNA fragmentation , it's very tempting to conclude that it's the sperm DNA fragmentation which is responsible for the fragmented embryos. However, this has never been proven ; and please remember this is not necessarily cause and effect. Men with higher sperm DNA fragmentation have had completely healthy and normal babies in their bedroom !

DNA fragmentation is a new parameter for the evaluation of male factor infertility . However, just because it is new does not automatically mean it is better ! In fact, at present it just seems to add to the confusion, rather than clarify it !
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Social Media and Medicine – a Match Made in Heaven? | MedCrunch

Social Media and Medicine – a Match Made in Heaven? | MedCrunch: "What about working with the new media in novel and valuable construct? The idea would be to engage all the players; clinicians, patients and industry. Users would complete a registration process and access a secure cloud. Individual disease, devices and medications would have a distinct information page with customized categories and questions relevant to a patient experience. Content would be assessed through an open on-line peer-review process and use material beyond the written word to minimize the potential for exclusion because of literacy or numeracy unmet needs."

A clever startup will use technology to marry PHRs with Information Therapy with social media, so patients can have intelligent conversations online with doctors , loved ones and other patients !
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Pharma marketing - what doctors need to know !

Pharma marketing - what doctors need to know : "Pharma marketing can be classified into two different categories:

1. Push marketing: targeting physicians. Urging them to “push” certain drugs to their patients.
2. Pull marketing: targeting patients. Urging them to “pull” or request certain drugs from their physicians.

The most important approach to marketing taken by many pharmaceutical companies has been push-oriented. All those busy pharma reps swirling around hospital hallways are trying to persuade you to prescribe their drugs to your patients.

Nevertheless, the pull-approach has become more and more prevalent these days. Pharma companies are increasingly targeting the patients themselves.
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Speak Up: Help Prevent Errors in Your Care


These brochures encourage patients and care recipients to become active, involved, and informed participants on the health care team. The message of the Speak Up program urges patients to

Speak up if you have questions or concerns, and if you don’t understand, ask again. It’s your body and you a have a right to know.

Pay attention to the care you are receiving. Make sure you’re getting the right treatments and medications by the right health care professionals. Don’t assume anything.

Educate yourself about your diagnosis, the medical tests you are undergoing, and your treatment plan.

Ask a trusted family member or friend to be your advocate.

Know what medications you take and why you take them. Medication errors are the most common health care errors.

Use a hospital, clinic, surgery center, or other type of health care organization that has undergone a rigorous on-site evaluation against established state-of-the-art quality and safety standards, such as that provided by The Joint Commission.

Participate in all decisions about your treatment. You are the center of the health care team.



Wednesday, March 16, 2011

Providing feedback to doctors to help them to learn

What makes a good doctor good is the fact that he has good clinical judgment. This is a term which is hard to define, but basically a good doctor is one has seen and treated and learned from lots of patients, each of whom adds to his knowledgebase and clinical wisdom. As the saying goes, "Good judgment comes from experience. Experience comes from bad judgment."

However, the mere passage of time does not provide good judgment . After all, 20 years of being a doctor could simply mean 20 years of doing the wrong thing ! It's important that doctors learn from their experience - and the only way they can do so is by tracking the outcomes of the patients they treat.

Unfortunately, this rarely happens in real life ! Let's take 2 patients whom a family physician treats for abdominal pain. One gets better and moves on with his life. He does not tell the doctor he is better, because who goes to a doctor when they are fine ? The other may get worse and may end up needing an appendectomy. However, he's not likely to go back to the doctor either ( unless he is angry and wants to sue !). This means that both patients who get better and those who don't rarely provide feedback to their doctor in real life.

However, without this feedback, how is the poor doctor going to learn ? He naively assumes all his patients have got better - and he loses track of those who do not improve , because unhappy patients will do their best to find another doctor.

How can doctors practise evidence based medicine ( EBM) without any evidence ? They need feedback from patients, so that can learn whether what they are doing doing is useful or not ?

EMRs can be a great tool in facilitating this kind of patient feedback ! One week after every clinical encounter, the system can automatically send an email to the patient, asking for feedback. This will provide very useful data - for which each doctor can learn about what he did right - and what he messed up.

Many doctors will agree that it can be very frustrating to treat an "interesting patient" - and then never find out how the story ends, because the patient never comes back and is "lost to followup" !

Not only will this data help doctors to learn and improve , it can also be very useful as a clinical practice builder , because patients are touched when their doctor reaches out to them proactively. Patients are happy when they learn that the doctor is interested in finding out how they are doing - and happy patients make for happy doctors !


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Tuesday, March 15, 2011

Patient safety through information therapy


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The value of a clomiphene citrate challenge test

Many older infertile women are very unsure as to whether they need to do IVF; and if they do need IVF, if they should use their own eggs or to use donor eggs. While they understand with their heads that using donor eggs would maximise their chances of getting pregnant, it's hard for their heart to accept this decision, because most of us want a genetic link with our child !

This is especially true for older women who have regular cycles; grow follicles on ultrasound scans ; or have had a miscarriage in the last 2-3 years. If my cycles are regular and I can get pregnant in my own bedroom, doesn't this prove my eggs are fine ?

Gynecologists ( who do not specialise in infertility treatment) will often add to this confusion. Because they see 42 year old women who get pregnant in their own bedroom, they fail to understand there is a big difference in the biology of a fertile 42 year old and an infertile 42 year old. They will often "treat" these older women with clomiphene and follicular monitoring - causing them to waste valuable time !

The more sophisticated doctors will get their patient's FSH levels tested - and if these are normal, this will lull them into a false sense of security ! Not only are FSH levels very poor markers of ovarian reserve, they also vary from month to month; and if they are checked without also testing the estradiol ( E2) level at the same time, you may get an apparently normal FSH level, even if the ovarian reserve is very poor. ( A high E2 level can suppress a high FSH level into the normal range, and fool both doctor and patient !)

Unfortunately, most older women do not want to hear bad news. They are often in a state of denial and are not happy to listen to an IVF specialist who tells them that their "eggs are bad" ! They confuse calendar age with ovarian age - and are even more perplexed when they go online and read success stories of older women with high FSH levels who have got pregnant in their own bedroom !

Who should they trust ? Is the IVF doctor pushing IVF because he wants to make more money ?
Or is he providing medically sound advise ? Will you regret not doing IVF ? Or do you have an equally good chance of making a baby in your own bedroom ? And what if the IVF cycle fails ? Then what ?

While it's true that we do have better tests today for checking ovarian reserve, such as the AMH level and the antral follicle count , it's hard to make such an emotionally charged decision based purely on the results of medical tests. How reliable are these tests ? Can the results improve with alternative medicine ? herbal supplements ? acupuncture ?

If you are unsure what to do , and are emotionally detached enough to make a decision based purely on medical testing, then please ask your doctor to do a clomiphene citrate challenge test ( CCT) for you. This is a simple , inexpensive test, which provides very valuable information; and has stood the test of time. When it's hard to make a decision and you are confused, sometimes basing your decision on an objective test result can help you overcome your paralysis and move on with your life !

How does one do this test ?

Day 1 = day the bleeding of the period starts

On Day 3 , you need to do a blood test to measure your levels of FSH,LH,PRL and TSH; and AMH ( anti-mullerian hormone). Do this from a reliable lab please !

Take 100 mg clomiphene citrate from Day 5 - Day 9.

Repeat the blood test for FSH again on Day 10.

If the Day 3 plus Day 10 FSH levels are less than 25, then we can try to do IVF with your own eggs.

If the Day 3 plus Day 10 FSH levels are more than 25, this suggests you have ovarian failure,
and that donor egg IVF would be your best treatment option, if you are willing to consider this. A low AMH level will help to confirm this diagnosis.

If you are not sure how to interpret your results , you can ask me for a free second opinion !

For the older woman, time is now at a premium for you - please don't waste it ! When you are 60 years old and looking back at your life, you should never have any regrets that you left any stone unturned and didn't give yourself the best shot at fertility treatment. Treatment can be expensive, but a baby is priceless !

Taking treatment at a world-class clinic will maximise your chances of success and give you peace of mind you did your best !


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Sunday, March 13, 2011

How couples reduce their own fertility

Infertile couples are often willing to move heaven and earth in order to have a baby. However, I find to my dismay that a lot of them do things which actually end up reducing their fertility !

1. They use lubricants while having sex which kill the sperm . Having "baby making sex" on demand is not much fun for either husband or wife - and it's quite common to have to use lubricants in order to be able to achieve intravaginal penetration. However, many couples will use lubricants such as K-Y jelly or saliva - both of which can kill the sperm ! If you do need to use a lubricant, please use a sperm friendly lubricant. The easiest one to buy ( and the cheapest one) is liquid paraffin. It' easy available OTC at a chemist - just look under the laxatives !

2. Timing sex. Most couples know that the wife is fertile for only a few days during the entire month. However, because they are quite clueless about what these fertile days actually are ( and do not whom to ask or how to calculate them), they often end up having sex on Day 14 ( which they remember vaguely from their high school biology class on human reproduction ( when they weren't busy pretending to be blase because they " knew it all" ; or were giggling and blushing) is the day when ovulation occurs and the egg is released). However, for many women, Day 14 can actually be an "infertile day " ( for example, for women whose cycles are 25 days or less) . Using the Free Fertility Calculator at www.myfertiletime.in will help you track your fertility ! Using OPKs can also help !

3. Not having enough sex. Many wives refuse to allow their husbands to have sex until their "peak fertility day". They believe that if they "store up the sperm" and then discharge this with a big bang, their chances of getting pregnant increase. Actually, this is not true. You cannot really store up the sperm - the count does go up when ejaculation is delayed - but it's the immotile sperm which increase - not the motile ones ! It's far more efficient t have frequent sex, as long as the sperm are going in the vagina !

4. Many infertile women still use BBT charting to try to track their fertile day. This is a big, big mistake. While BBT charting does provide useful evidence to the doctor , it's only retrospective evidence - it does not help to identify the fertile days, as the BBT raises only after ovulation has occurred ( at which time the cervical mucus dries up and sperm can no longer enter the uterus and swim up to the egg).

5. Not doing any homework. It still astonishes me as to how poorly informed many infertile couples are about the basics of baby making ! They will often waste time trying herbs and supplements advertised on dodgy websites to "boost their sperm count"; or take "fertility tablets" to increase their fertility. They will allow months to run into years before seeking medical attention - or even doing a basic ( and inexpensive) fertility workup, to confirm that everything this fine.
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Thanks, Dr Malpani !

This is an email a patient from Nigeria sent me today.

" I have set aside this morning to commend you and your beautiful wife on the good work you are doing for humanity. You give hope to the hopeless, healing our wounds of years by showing commitment and concern, even when the situation looks gloomy. You are ready to even pray for mercy and help for your patients! I am impressed.

I have discovered that IVF is a journey. The travellers are the patients, but all of us will have to travel by different means of transportation, The luckiest by air, some by sea, others by road. It means there will be travellers by jet, speedboat, canoe, ships, cars, bikes, rail or even trucks and cartwheels! I am happy you guys are the drivers and my prayer is that the Almighty Creator will always grant you the wisdom to choose the right means of transportation, and the patience/perseverance to convey your travellers to their desired destination.

Please keep up the good work. I love you both and appreciate you."


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Saturday, March 12, 2011

Moments of truth in an IVF cycle

An IVF cycle is full of uncertainty and suspense , like any other biological system. However, being prepared for these can help you cope better !

Think of an IVF cycle as being a series of hurdles - and you need to cross all these to reach the finish line ! While most patients will cross these hurdles with ease in a good IVF clinic, each of these is a " moment of truth ".

  • You should grow many follicles
  • These follicles should mature
  • Your uterine lining should also mature in synch with your follicles
  • Ovulation should not occur before the eggs can be collected
  • Mature eggs must be retrieved by the doctor during the "pick-up"
  • Your sperm must fertilize the eggs ( with IVF or ICSI)
  • The embryos must divide and grow healthily in the IVF lab
  • Your embryos should be transferred by the doctor smoothly into your uterus
  • Your embryos should implant

Think of it as a series of hurdles, all of which have to be cleared , in order to win the race !

As you can see, how well you negotiate these hurdles will depend to some extent on your biology ( how good your ovarian reserve is , for example); while others will depend upon the skill of the doctor !

A good clinic will guide you through these moments of truth, and share information with you, so that you can rejoice when things are going well - and be prepared in case things do not go as planned. Unfortunately, as with any biological system, IVF is also full of ups and downs - and the more you know about what is happening - and what is going to happen next, the more easily you'll be able to go through your IVF treatment !
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Friday, March 11, 2011

Why should I select Malpani Infertility Clinic for my surrogacy treatment ?

I just received this thoughtful questionnaire from a patient.

We are looking for “gestational surrogacy” in India. There are many clinics offering these services and before moving forward in this decision, we want to have more information about your clinic and some steps of the process. Here are our questions and concerns.


1. How many years of experiences in fertility and surrogacy does your clinic have?

20 years

2. What are the main steps and what is the time table of the whole process
a. Steps

The process is described in details at www.indiansurrogates.in

b. Timeframe

20 days

3. What is the delay from first contact to start of surrogacy?

3-4 months

4. What are the legal concerns with surrogacy?

Our legal consultant will take you through these

5. What are the legal procedures we have to go through?

Our legal consultant will draft the contract which you and the surrogate will have to sign before we start your treatment

6. What is the selection process for the surrogates?

We select the surrogate for you. We screen them for their health; and to rule out infectious diseases; and counsel them as well


7. What facilities do you provide and what control do you then have with surrogates?

The surrogate’s pregnancy is monitored by our obstetric consultant

8. What is the cost and what does it include?

US $ 25000

9. What other expenses / costs (not included) that are at my charge?

Travel

10. How much goes to the surrogate and how much goes to the clinic?

Described at www.indiansurrogates.in

11. What is the probability of success/failure?

Our pregnancy rate is 56% when we transfer 3 Grade A embryos

12. Has there ever been health related issues when the new born is taken back to the parents’ country?

No

13. Do you have a blog webpage where parents can share their experience with your clinic?

You can talk to some of our patients by email at www.drmalpani.com/ivfsuccessstories.htm

14. Why should we select your clinic more than another?

You can read about how we pamper our patients at http://www.drmalpani.com/ivf-treatment-at-malpani-ivf-clinic.htm






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